Current status of Type 2 (non-insulin-dependent) diabetic subjects on dialysis therapy in Japan

Summary

According to a national survey of dialysis patients in Japan conducted by the Japanese Society for Dialysis Therapy, there were 1,033 patients on dialysis in the Shiga area which has a population of about 1.2 million. Of these 1,033 dialysis patients 140 were the result of diabetic nephropathy. From four hospitals affiliated to Shiga University of Medical Science the medical records of 90 diabetic subjects on dialysis therapy were reviewed and various clinical parameters were analysed and compared with those of patients with chronic glomerulonephritis. Since only one patient had Type 1 (insulin-dependent) diabetes, the remaining 89 with Type 2 (non-insulin-dependent) diabetes were used for this study. The significantly different variables between patients with Type 2 diabetes and chronic glomerulonephritis were age (60.4 vs 54.6 years,p<0.05), BMI (22.4 vs 20.6 kg/m²,p<0.001), cardiothoracic ratio (56.4 vs 53.3%,p<0.001), mean blood pressure (110 vs 117 mm Hg,p<0.05), serum creatinine (9.0 vs 11.5 mg/dl,p<0.001), serum urea-N (98.2 vs 115.5 mg/dl,p<0.001), serum total protein (6.0 vs 6.5 g/dl,p<0.001) and serum albumin (3.5 vs. 3.9 g/dl,p<0.001). Serum levels of cholesterol and triglyceride were not significantly different between two groups, though the prevalence of electrocardiogram abnormalities, oedema, neuropathy, myocardial infarction and cerebrovascular diseases was significantly higher in the Type 2 diabetic group. These results suggested that Type 2 diabetic patients with end-stage renal disease were older, more malnurished, fluid overloaded and multi-morbid as a result of vasculopathy and neuropathy. However, the analysis of causes of death in Type 2 diabetic patients (n=24) and patients with chronic glomerulonephritis (n=26) failed to provide evidence of higher risk of cardiac death in the Type 2 diabetic group compared to the group with chronic glomerulonephritis (37.5 vs 34.6%, NS). In the Type 2 diabetic patients on dialysis therapy, malnutrition, fluid overload and neuropathy appeared to be significant factors influencing the outcome of the therapy, while in patients with chronic glomerulonephritis, age and vascular morbidities were considered to be major risk factors for the prognosis.