Summary
Mitochondrial DNA is exclusively maternally inherited. We recently found the prevalence of diabetic patients with an A to G transition at position 3243 of leucine tRNA (3243 base pair (bp) mutation) to be nearly 1 % in randomly selected Japanese subjects. Here, we report the higher prevalence of diabetic patients with the 3243 bp mutation in a specific Japanese population of women attending a diabetic pregnancy clinic. Of 102 patients with non-insulin-dependent diabetes mellitus 6 (5.9 %) were positive for the mutation, 1 (8.3%) of 12 patients with gestational diabetes and 2 (5.9 %) out of 34 borderline diabetic patients. In contrast, none of 64 patients (0%) with insulin-dependent diabetes mellitus had the 3243 bp mutation. Moreover, there was a difference in the prevalence of spontaneous abortions between patients with and without this mutation (27.3 vs 12.4%). Among nine probands with the mutation, four had a history of one spontaneous abortion (p = 0.0518) and two had a history of two abortions (p = 0.0479). Two probands had a spontaneous abortion even while under strict diabetic metabolic control. The 3243 bp mutation thus may cause spontaneous abortion during pregnancy.
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Abbreviations
- IDDM:
-
insulin-dependent diabetes mellitus
- NIDDM:
-
non-insulin-dependent diabetes mellitus
- PCR:
-
polymerase chain reaction
- PCDW:
-
pregnancy clinic for diabetic women'
- GDM:
-
gestational diabetes mellitus
- GAD:
-
glutamic acid decarboxylase
- OGTT:
-
oral glucose tolerance test
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Yanagisawa, K., Uchigata, Y., Sanaka, M. et al. Mutation in the mitochondrial tRNAleu at position 3243 and spontaneous abortions in Japanese women attending a clinic for diabetic pregnancies. Diabetologia 38, 809–815 (1995). https://doi.org/10.1007/s001250050357
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DOI: https://doi.org/10.1007/s001250050357