Summary
After sham-feeding of glucose, conscious trained dogs bearing double-barrelled fistulas of the oesophagus or of the stomach do not show any blood sugar increase. Nevertheless their IRI-levels in the peripheral venous blood increased considerably. This increase consists of two peaks of short duration between the 5th and the 10th as well as the 15th and the 25th min. Such IRI-peaks oceured also after sham-feeding of tap water, but to a smaller extent. Their temporal order corresponds to the early IRI-peaks after oral glucose administration in intact animals, but before the blood glucose increase which was observed by us previously. After the application of glucose into the oral opening of the oesophageal fistula the first IRI-peak does not occur, the second and the third peaks appeared to the same extent. A feed-forward of insulin secretion induced by oral ingestion is suggested. It may be interpreted within the scope of the “entero-insular axis” of the mechanism of insulin secretion.
Résumé
Des chiens éveillés et entraînés portant des fistules de l'oesophage ou de l'estomac ne présentent aucune élévation du sucre sanguin après alimentation simulée de glucose, néanmoins une augmentation considérablede la concentration insulinique dans le sang veineux périphérique apparaît. Celle-ci consiste en deux pics bref s entre la 5 e et la 10 e min et aussi entre la 15 e et la 25 e min. Ces deux pics apparaissent aussi après alimentation simulée d'eau potable, mais à un moindre degré. Leur ordre chronologique correspond aux pics précoces d'IRI que nous avons observés antérieurement, après administration orale de glucose chez des animaux intacts, avant l'élévation glycémique réelle. Après application de glucose dans l'ouverture aborale de la fistule chez des animaux portant une fistule de l'oesophage, il manque le premier pic d'IRI, le deuxième et le troisième pic (provoqués par résorption) apparaissent invariablement. Une insulino-sécrétion intensifiée, couplée à la prise de nourriture et induite par l'ingestion orale est suggérée et discutée dans le cadre de l'«entero-insular axis» du mécanisme de l'insulino-sécrétion.
Zusammenfassung
Wache trainierte Hunde mit doppelläufigen Fisteln des Oesophagus oder des Magens zeigen nach Scheinfütterung mit Glucose keinen Blutzucker -anstieg, aber eine sichere Erhöhung des immunchemisch gemessenen Seruminsulins im peripheren Venenblut. Es wurden zwei kurzzeitige Peaks zwischen der 5. und 10. sowie der 15. und 25. min beobachtet. In geringerem Ausmaß fanden sich diese beiden Peaks auch nach Scheinfütterung mit Leitungswasser. Sie entsprechen in ihrer zeitlichen Anordnung den von uns früher beobachteten frühen Insulingipfeln nach oraler Glucosegabe an intakte Tiere vor dem eigentlichen Blutzuckeranstieg. Bei Glucoseverabfolgung in die aborale Fistelöffnung von Oesophagusfistelträgern fehlt der erste IRI-Gipfel, der zweite und der dritte (resorptionsbedingte) sind unverändert ausgeprägt. Es wird eine von Rezeptoren der Mundhöhle ausgelöste Vorwärtskopplung der Insulinsekretion bei oraler Verabfolgung stimulierender Substanzen angenommen und im Rahmen der „enteroinsulinären Achse“ des Insulininkretionsmechanismus diskutiert.
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Hommel, H., Fischer, U., Retzlaff, K. et al. The Mechanism of Insulin Secretion after Oral Glucose Administration. Diabetologia 8, 111–116 (1972). https://doi.org/10.1007/BF01235635
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DOI: https://doi.org/10.1007/BF01235635