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Effect of CO2-induced hyperventilation on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning

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Abstract

To study under standardized experimental conditions the effect of a CO2-induced hyperventilation therapy on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning, rats received 2.5 ml CCl4/kg BW by gastric intubation and were subsequently either treated by CO2-induced hyperventilation or kept in an atmosphere containing air. Peak levels of CCl4 were observed in the fat, liver and blood 3–6 h after the intoxication and were found to be considerably lower in animals treated by CO2-induced hyperventilation compared to their respective controls. These data therefore strongly support the efficacy of the CO2-induced hyperventilation therapy for CCl4 intoxication.

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  1. Medizinische Klinik D der Universität Düsseldorf, Moorenstraße 5, D-4000, Düsseldorf, FRG

    J. Gellert, L. Goldermann &  R. Teschke

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  1. J. Gellert
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  2. L. Goldermann
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  3. R. Teschke
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Gellert, J., Goldermann, L. & Teschke, R. Effect of CO2-induced hyperventilation on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning. Intensive Care Med 9, 333–337 (1983). https://doi.org/10.1007/BF01692552

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