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Analysis of haemoperfusion columns for evaluation of treatment of phenobarbital overdosage

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Abstract

A simple procedure for the extraction of phenobarbital from charcoal haemoperfusion columns is presented. This method enables to evaluate the efficacy of treatment of poisoned patients with haemoperfusion. The applicability of this procedure is tested with four columns which were used in the treatment of two patients with severe phenobarbital intoxication. When an appropriate internal standard and solvent are used, this method is applicable for any drug.

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Authors and Affiliations

  1. Laboratory of Toxicology, University Hospital, 2333, AA Leiden, The Netherlands

    Frederik A. de Wolff & Nicole D. Smit

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  1. Frederik A. de Wolff
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  2. Nicole D. Smit
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de Wolff, F.A., Smit, N.D. Analysis of haemoperfusion columns for evaluation of treatment of phenobarbital overdosage. Arch Toxicol 43, 233–235 (1980). https://doi.org/10.1007/BF00297589

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  • DOI: https://doi.org/10.1007/BF00297589

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