Abstract
The content and retention of manganese in the blood and brain of mice exposed to different forms of the metal was compared. Mice received an acute sc injection of manganese as the chloride or oxide (Mn3O4) or as the organic MMT. A single injection markedly elevated brain manganese concentrations within 1 day and elevated levels were maintained for at least 21 days. Repeated injections led to further increases in both brain and blood, although the levels in the brain appeared to persist at consistently high levels for longer periods. The chloride form produced higher brain levels than either of the other two forms. These results appear to suggest that the slowly developing neurotoxicity in response to manganese exposure may be due to a persistent retention of manganese by the brain.
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References
Bonilla E (1980) l-tyrosine hydroxylase activity in the rat brain after chronic oral administration of manganese chloride. Neurobehav Toxicol 2: 37–41
Cahill DF, Bercegeay MS, Haggerty RC, Gerding JE, Gray LE (1980) Age-related retention and distribution of ingested Mn3O4 in the rat. Toxicol Appl Pharmacol 53: 83–91
Cotzias GC (1958) Manganese in health and disease. Physiol Rev 38: 503–532
Exon JH, Koller LD (1975) Effects of feeding manganese antiknock gasoline additive exhaust residues (Mn304) in rats. Bull Env Cont Tox 14: 370–373
Gianutsos G, Murray MT (1982) Alterations in brain dopamine and GABA following inorganic or organic manganese administration. Neurotoxicology 3: 75–82
Mena I, Marin O, Fuenzalida S, Cotzias GC (1967) Chronic manganese poisoning. Neurology 17: 128–136
Moore W, Hall L, Crocker W, Adams J, Stara JF (1974) Metabolic aspects of methylcyclopentadienyl manganese tricarbonyl in rats. Environ Res 8: 171–177
Paynter DI (1979) Microdetermination of manganese in animal tissue by flameless atomic absorption spectrometry. Anal Chem 51: 2986–2089
Rehnberg Gl, Hein JF, Carter SD, Linko RS, Laskey JW (1981) Chronic ingestion of Mn3O4 by young rats: Tissue accumulation, distribution, and depletion. J Toxicol Environ Hlth 7: 263–272
Tandon SK, Chandra SV (1978) Regional distribution of manganese in brain of experimentally poisoned rabbits. Chemosphere 2: 185–191
Thompson TN, Klaassen CD (1982) Presystemic elimination of manganese in rats. Toxicol Appl Pharmacol 64: 236–243
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Gianutsos, G., Seltzer, M.D., Saymeh, R. et al. Brain manganese accumulation following systemic administration of different forms. Arch Toxicol 57, 272–275 (1985). https://doi.org/10.1007/BF00324791
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DOI: https://doi.org/10.1007/BF00324791