Abstract
Two monoclonal antibodies (Vx-BB8 and Vx-EA11) to the chemical warfare agent Vx were produced and characterized. A competitive inhibition enzyme immunoassay was developed to detect Vx concentrations as low as 3.7×10−7–3.7×10−6 mol/l in biological samples. Vx-BB8 400 μg given intravenously immediately before 1×LD95 Vx or 400 μg Vx-BB8 intraperitoneally 1.5 h−3 days before 1×LD95 Vx could protect all the tested mice from death.
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Ci, Yx., Zhou, Yx., Guo, Zq. et al. Production, characterization and application of monoclonal antibodies against the organophosphorus nerve agent Vx. Arch Toxicol 69, 565–567 (1995). https://doi.org/10.1007/s002040050213
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DOI: https://doi.org/10.1007/s002040050213