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In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test

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Abstract

The herbicides alachlor, atrazine, terbuthylazine, gluphosinate-ammonium, isoproturon, pendimethaline and trifluralin were tested for genotoxicity in the mouse bone-marrow micronucleus test (MNT). Both atrazine and trifluraline caused a significant increase in the number of micronuclei at doses of 1400 mg/kg body weight in female mice only. Alachlor, terbuthylazine, gluphosinate-ammonium, isoproturon and pendimethaline did not have any genotoxic effect in the mouse bone-marrow micronucleus test in either female or male animals.

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Authors and Affiliations

  1. Medical Institute for General Hygiene and Environmental Health, Georg-August-Universität, Windausweg 2, D-37073 Göttingen, Germany, , , , , , DE

    T. Gebel, S. Kevekordes & H. Dunkelberg

  2. Institute of Medical Microbiology and Hygiene, Department of Hygiene, Johannes-Gutenberg-Universität, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany, , , , , , DE

    K. Pav & R. Edenharder

Authors
  1. T. Gebel
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  2. S. Kevekordes
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  3. K. Pav
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  4. R. Edenharder
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  5. H. Dunkelberg
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Received: 20 June 1996 / Accepted: 11 September 1996

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Gebel, T., Kevekordes, S., Pav, K. et al. In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test. Arch Toxicol 71, 193–197 (1997). https://doi.org/10.1007/s002040050375

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  • DOI: https://doi.org/10.1007/s002040050375

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