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Ein Substanz P-Standardpräparat

A standard preparation of substance P

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Summary

  1. 1.

    Fraction Fa of crude substance P (SP), made from brain and gut, causes, in contrast to the SP peptide Fb, a relaxation of the isolated rat duodenum. Fraction Fa is therefore not a suitable SP standard preparation.

  2. 2.

    By means of sephadex gel filtration, a relaxing component can be separated from the contracting Fa peptide.

  3. 3.

    The relaxing Fa component is acidic, but is neither a peptide nor prostaglandinF 2α.

  4. 4.

    Purified Fa material from brain is recommended as SP standard preparation.

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Authors and Affiliations

  1. Institut für Pharmakologie der Medizinischen Akademie Lübeck, Deutschland

    J. Baldauf & K. Gebhardt

  2. Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, 6650, Homburg (Saar)

    J. Baldauf

Authors
  1. J. Baldauf
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  2. K. Gebhardt
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Baldauf, J., Gebhardt, K. Ein Substanz P-Standardpräparat. Naunyn-Schmiedebergs Arch. Pharmak. 265, 278–286 (1969). https://doi.org/10.1007/BF01002341

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  • DOI: https://doi.org/10.1007/BF01002341

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