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The effect of brocresine (NSD-1055) on diamine oxidase activity in plasma, liver, stomach and upper small intestine of rats

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Summary

  1. 1.

    In male rats DAO was found to be absent in plasma and liver, very low in gastric and high in the upper small intestinal mucosa.

  2. 2.

    Gastric mucosal DAO was completely abolished by 10−8 M Brocresine. In the small intestine inhibition of DAO by Brocresine was dose-dependent, with a concentration of 6.2×10−6 M producing a 50% inhibition of the enzyme.

  3. 3.

    Pretreatment of rats with 100 mg/kg Brocresine i.p. produced a 43% inhibition of DAO after 1 h and an insignificant inhibition by 20% after 4 h.

  4. 4.

    The results suggest that the histidine decarboxylase inhibitor Brocresine is not a very suitable tool for studying the physiological role of histamine by inhibiting its biosynthesis since it also interferes with the histamine catabolism.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Tübingen, Germany

    Barbara Binder & K. -Fr. Sewing

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  1. Barbara Binder
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  2. K. -Fr. Sewing
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Supported by the Deutsche Forschungsgemeinschaft.

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Binder, B., Sewing, K.F. The effect of brocresine (NSD-1055) on diamine oxidase activity in plasma, liver, stomach and upper small intestine of rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 425–430 (1973). https://doi.org/10.1007/BF00501484

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  • DOI: https://doi.org/10.1007/BF00501484

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