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Influence of various corticoids on the augmentation of “Gomori-positive” granules in the median eminence of the rat following adrenalectomy

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Summary

In 465 female Wistar rats the influence of an i.m. injection of various natural or synthetic corticoids on the augmentation of “Gomori-positive” granules in the outer layer of the median eminence following bilateral adrenalectomy has been investigated. While the augmentation of the granules is not impaired by progesterone it is inhibited or completely blocked, depending on the dose and the manner of application, by 11-desoxycorticosterone, corticosterone, cortisol, 9α-fluorocortisol, prednisolone, triamcinolone, dexamethasone and fluoroformylone. The doses necessary to suppress the augmentation of the granules correspond to those shown by other authors to be required for blocking ACTH-secretion. The inhibitory effect of the investigated corticoids on the augmentation of the granules is related to their antiphlogistic potency.

The findings suggest that the amount of the “Gomori-positive” granules in the outer layer of the median eminence of the rat might be used as a parameter of the activity of the corticotropin-releasing factor.

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  1. Institut für Anatomie der Universität Bonn, Germany

    H. Brinkmann & R. Bock

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Brinkmann, H., Bock, R. Influence of various corticoids on the augmentation of “Gomori-positive” granules in the median eminence of the rat following adrenalectomy. Naunyn-Schmiedeberg's Arch. Pharmacol. 280, 49–62 (1973). https://doi.org/10.1007/BF00505354

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