Summary
Rats were injected i.v. with 125I-tetanus toxin. In autoradiographs of the spinal cord radioactivity was found over the pericarya and in the surroundings of the motoneurones whereas grain density was less over their nuclear region. In addition, pericarya in the lateral horn of the thoracic region and also the bipolar cells of the spinal ganglia contained radioactivity. The central part and the dorsal horns of spinal cord, and the white substance did not show any appreciable radioactivity. Within the medulla oblongata, clusters of large cells representing motor nuclei, as well as some fibre tracts close to them, contained 125I. Forebrain and cerebellum remained free.
According to its histoautoradiographic appearance, generalized tetanus can be described best as a combination of multiple local tetani.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Dimpfel, W., Habermann, E.: Histoautoradiographic localization of 125I-labeled tetanus toxin in rat spinal cord. Naunyn-Schmiedeberg's Arch. Pharmacol. 280, 177–182 (1973)
Erdmann, G., Wiegand, H., Wellhöner, H.H.: Intraaxonal and extraaxonal transport of 125I-tetanus toxin in early local tetanus. Naunyn-Schmiedeberg's Arch Pharmacol. 290, 357–373 (1975)
Habermann, E., Dimpfel, W.: Distribution of 125I-tetanus toxin and 125I-toxoid in rats with generalized tetanus, as influenced by antitoxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 327–340 (1973)
Habermann, E., Dimpfel, W., Räker, K. O.: Interaction of labelled tetanus toxin with substructures of rat spinal cord in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 361–373 (1973)
Habermann, E., Wellhöner, H. H., Räker, K. O.: Metabolic fate of 125I-tetanus toxin in the spinal cord of rats and cats with carly local tetanus. Naunyn-Schmiedeberg's Arch. Pharmacol. 299, 187–196 (1977)
Meyer, F., Ransom, H.: Untersuchungen über den Tetanus. Arch. Exp. Path. Pharmakol. 49, 369–416 (1903)
Paar, G. H., Wiegand, H. J., Wellhöner, H. H.: The influence of tetanus toxin on sympathetic reflex discharges into the renal nerves. Naunyn-Schmiedeberg's Arch. Pharmacol. 281, 383–390 (1974)
Price, D. L., Griffin, J. W.: Tetanus toxin: Retrograde axonal transport of systemically administered toxin. Neurosci. Letters 4, 61–65 (1977)
Price, D. L., Griffin, J. W., Peck, K.: Tetanus toxin: evidence for binding at presynaptic nerve endings. Brain Res. 121, 379–384 (1977)
Price, D. L., Griffin, J., Young, A., Peck, K., Stocks, S.: Tetanus toxin: Direct evidence for retrograde intraaxonal transport. Science 188, 945–947 (1975)
Stöckel, K., Schwab, M., Thoenen, H.: comparison between the retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neurones. Brain Res. 99, 1–16 (1975)
Wernig, A., Stöver, H., Tonge, D.: The labelling of motor endplates in skeletal muscle of mice with 125I tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 298, 37–42 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Erdmann, G., Habermann, E. Histoautoradiography of central nervous system in rats with generalized tetanus due to 125I-toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 301, 135–138 (1977). https://doi.org/10.1007/BF00501428
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00501428