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Studies with a tritium-labeled psychotomimetic agent

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Summary

The distribution of tritium-labeled JB 318 (N-ethyl-3-piperidyl benzilate) was studied in rats. Over 95% of the drug was excreted by way of the kidneys within 2 hours after administration. About 0.1% of the total drug was found in the central nervous system with the largest cencentration in the caudate nucleus and hypothalamus. Over 60% was bound to the mitochondria of brain with the remainder equally distributed between the supernatant and nuclear-debris fraction. The drug appears to be tightly bound to mitochondria, since it is released with great difficulty.

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Author notes

  1. F. Rinaldi

    Present address: Abbott Laboratories, North Chicago, Illinois

Authors and Affiliations

  1. Division of Psychiatry, University of Illinois College of Medicine, USA

    L. G. Abood & F. Rinaldi

Authors
  1. L. G. Abood
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  2. F. Rinaldi
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Additional information

This research was supported jointly by the Mental Health Fund, State of Illinois, and the Teagle Foundation.

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Abood, L.G., Rinaldi, F. Studies with a tritium-labeled psychotomimetic agent. Psychopharmacologia 1, 117–123 (1959). https://doi.org/10.1007/BF00409111

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  • DOI: https://doi.org/10.1007/BF00409111

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