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Impairment by lysergic acid diethylamide of accuracy in performance of a delayed alternation test in monkeys

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Summary and Conclusions

Monkeys were found to show impairment in performing the delayed alternation problem following injections of LSD in initial doses as low as 0.005 mg/kg. The effect of this drug was primarily reflected in a decrease in accuracy of response, although increasingly large doses tended also to depress the rate of performance. Tolerance to the effects of LSD rapidly developed and persisted for several days, at least.

Unlike LSD, amphetamine, pentobarbital and chlorpromazine either did not produce changes in accuracy, or when they did, these changes were relatively small compared to the effects of these drugs on the pressing rate. The possibility is suggested that the partial similarity of the effects of LSD to those obtained in monkeys following bifrontal lesions may reflect the operation of some common factor.

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References

  • Blough, D. S.: Some effects of drugs on visual discrimination in the pigeon. Ann. N.Y. Acad. Sci. 66, 733–739 (1957).

    PubMed  Google Scholar 

  • Blum, J., K. L. Chow and R. A. Blum: Delayed response performance of monkeys with frontal removal after excitant and sedative drugs. J. Neurophysiol. 3, 195–202 (1951).

    Google Scholar 

  • Bradley, P. B., and J. Elkes: The effects of some drugs on the electrical activity of the brain. Brain 80, 77–117 (1957).

    PubMed  Google Scholar 

  • Brady, J. V.: A comparative approach to the evaluation of drug effects upon affective behavior. Ann. N.Y. Acad. Sci. 64, 632–943 (1956).

    PubMed  Google Scholar 

  • Chow, K. L., and J. P. Hutt: The “association cortex” of Macaca mulatta: a review of recent contributions to its anatomy and functions. Brain 76, 625–677 (1953).

    PubMed  Google Scholar 

  • Cook, L., and E. Weidley: Behavioral effects of some psychopharmacological agents. Ann. N.Y. Acad. Sci. 66, 740–752 (1957).

    PubMed  Google Scholar 

  • Evarts, E. V.: Neurophysiological correlates of pharmacologically induced behavioral disturbances. In: The brain and human behavior. Proceedings of ARNMD, vol. XXXVI, p. 347–380. Baltimore: Williams & Wilkins Company 1958.

    Google Scholar 

  • Fuster, J. M.: Tachistoscopic perception in monkeys. Fed. Proc. 16, 43 (1957).

    Google Scholar 

  • Gogerty, J. H., and J. H. Dille: Tolerance to the pyretogenic effect of lysergic acid diethylamide. J. Pharmacol. exp. Ther. 116, 450–452 (1956).

    PubMed  Google Scholar 

  • Hall, J. F., J. M. Warren and H. F. Harlow: The effects of reserpine (Serpasil) on the delayed response in monkeys. J. Psychol. (Provincetown) 40, 159–161 (1955).

    Google Scholar 

  • Isbell, H., H. F. Fraser, A. Wikler and R. E. Belleville: Tolerance to diethylamide of lysergic acid. Fed. Proc. 14, 354 (1955).

    Google Scholar 

  • Jarvik, M. E., H. A. Abramson and M. W. Hirsch: Lysergic acid diethylamide (LSD-25). VI. Effect upon recall and recognition of various stimuli. J. Psychol. (Proviucetown) 39, 443–454 (1955).

    Google Scholar 

  • Meyer, D. R.: Food deprivation and discrimination reversal learning of monkeys. J. exp. Psychol. 41, 10–16 (1951).

    PubMed  Google Scholar 

  • Miles, C.: Discrimination in the squirrel monkey as a function of deprivation and problem difficulty. J. exp. Psychol. 57, 15–19 (1959).

    PubMed  Google Scholar 

  • Mishkin, M., and K. H. Pribram: Analysis of the effects of frontal lesions in monkeys: X. Variations of delayed alternation. J. comp. physiol. Psychol. 48, 492–495 (1955).

    PubMed  Google Scholar 

  • —, Effects of Nembutal in baboons with frontal lesions. J. Neurophysiol. 16, 155–159 (1953).

    PubMed  Google Scholar 

  • Rosvold, H. E., M. Mishkin and M. K. Szwarcbart: Effects of subcortical lesions in monkeys on visual discrimination and single-alternation performances. J. comp. physiol. Psychol. 51, 437–444 (1958).

    PubMed  Google Scholar 

  • Wade, M.: The effect of sedatives upon delayed response in monkeys following removal of the prefrontal lobes. J. Neurophysiol. 10, 57–62 (1947).

    Google Scholar 

  • Wikler, A.: The relation of psychiatry to pharmacology. Baltimore: Williams & Wilkins Company 1957.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Albert Einstein College of Medicine, New York

    Murray E. Jarvik & Stephan Chorover

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  1. Murray E. Jarvik
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  2. Stephan Chorover
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This research was supported in part by USPHS grant M-1225c2.

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Jarvik, M.E., Chorover, S. Impairment by lysergic acid diethylamide of accuracy in performance of a delayed alternation test in monkeys. Psychopharmacologia 1, 221–230 (1960). https://doi.org/10.1007/BF00402743

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  • DOI: https://doi.org/10.1007/BF00402743

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