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Effects of chlorpromazine and methamphetamine on sociability in rats

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Abstract

Using a time-sample photographic method three measures of sociability showed, contrary to some previous findings, rats administered chlorpromazine (3 mg/kg) to be more sociable than those treated with methamphetamine (2 mg/kg) or isotonic saline. Saline animals were more sociable than amphetamine-treated subjects on two measures. This illustrative study demonstrates that variables influencing sociability results may include social conditions in the cage, post-injection and test environments, and the measure employed.

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Syme, L.A., Syme, G.J. Effects of chlorpromazine and methamphetamine on sociability in rats. Psychopharmacologia 32, 81–84 (1973). https://doi.org/10.1007/BF00421709

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  • DOI: https://doi.org/10.1007/BF00421709

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