Abstract
Factorial analysis of rat cerebral 5-HT values observed following intraperitoneal LSD-25 and UML (1-methyl-d-lysergic acid butanolamide) showed that the highly significant decrease induced by both drugs was independent of dose and that the effect of both drugs was the same. Increased platelet 5-HT values were also obtained with each drug. These findings suggest that the psychotomimetic effect of LSD-25 is not due to changes in cerebral 5-HT, since a relationship can probably be postulated between such an effect in man and the effect of LSD-25 on conditioned behaviour in the rat. It is also felt that the fact that these drugs decrease and increase cerebral and platelet values respectively may be of assistance in the interpretation of data relating to platelet 5-HT patterns in man under psychiatric conditions and during treatment with psychotropic drugs.
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Torre, M., Bogetto, F. & Torre, E. Effect of LSD-25 and 1-methyl-d-lysergic acid butanolamide on rat brain and platelet serotonin levels. Psychopharmacologia 36, 117–122 (1974). https://doi.org/10.1007/BF00421783
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DOI: https://doi.org/10.1007/BF00421783