Abstract
Evidence is presented that learned safety increases the rat's willingness to drink ethanol; induction of tolerance to ethanol following learned safety training produces a further increase. Rats with chronically implanted intragastric fistulae consumed substantially more (30%) alcohol when aversive post-ingestional effects were minimized by draining stomach contents during drinking than did rats allowed to retain stomach contents. Half the rats from each group were then made tolerant by prolonged forced alcohol intubation. Later testing showed an increase in alcohol consumption by rats receiving learned safety training or rendered tolerant, with the two factors being additive.
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References
Berman, R. F., Cannon, D. S.: The effect of prior ethanol experience on ethanol-induced saccharine aversions. Physiol. Behav. 12, 1041–1044 (1974)
Deutsch, J. A., Eisner, A.: Ethanol self-administration in the rat induced by forced drinking of ethanol. Behav. Biol. 20, 81–90 (1977)
Deutsch, J. A., Hardy, W. T.: Ethanol tolerance in the rat measured by the untasted intake of alcohol. Behav. Biol. 17, 379–389 (1976)
Deutsch, J. A., Koopmans, H. S.: Preference enhancement for alcohol by passive exposure. Science 179, 1242–1243 (1973)
Deutsch, J. A., Walton, N. Y.: A rat alcoholism model in a free-choice situation. Behav. Biol. 19, 349–360 (1977)
Eckhardt, M. J.: The role of orosensory stimuli from ethanol and blood-alcohol levels in producing conditioned taste aversion in the rat. Psychopharmacologia (Berl.) 44, 267–271 (1975)
Hardy, W. T., Deutsch, J. A.: Preference for ethanol in dependent rats. Behav. Biol. 20, 482–492 (1977)
Kalant, H., LeBlanc, A. E., Gibbins, R. J.: Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol. Rev. 23, 135–191 (1971)
Kalat, J. W., Rozin, P.: Learned safety as a mechanism in long-delay taste-aversion learning in rats. J. Comp. Physiol. Psychol. 83, 198–207 (1973)
Lester, D., Freed, E. X.: Criteria for an animal model of alcoholism. Pharmacol. Biochem. Behav. 1, 103–107 (1973)
Majchrowicz, E.: Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia (Berl.) 43, 245–254 (1975)
Mello, N. K.: A review of methods to induce alcohol addiction in animals. Pharmacol. Biochem. Behav. 1, 89–101 (1973)
Myers, R. D., Veale, W. L.: The determinants of alcohol preference in animals. In: The biology of alcoholism, vol. 2, B. Kissin and H. Begleiter, eds. New York: Plenum 1972
Rozin, P., Kalat, J. W.: Specific hungers and poison avoidance as adaptive specializations of learning. Psychol. Rev. 78, 459–486 (1971)
Wallgren, H., Barry, III, H.: Actions of alcohol, vol. 1, Ch 8. Amsterdam: Elsevier 1970
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Walton, N.Y., Roll, P.L., Thiel, T.R. et al. Effects of learned safety and tolerance on alcohol consumption by the rat. Psychopharmacology 57, 263–266 (1978). https://doi.org/10.1007/BF00426748
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DOI: https://doi.org/10.1007/BF00426748