Abstract
The effects of 7-chloro-5-(2-fluorophenyl)-1-methyl-1 H, 1·4-benzodiazepin-2(3 H)-one (ID-540), a recently introduced benzodiazepine derivative, on the averaged photopalpebral reflex (PPR), subjective symptoms, and serum levels of ID-540 and its principal metabolite, N-desmethyl-ID-540, following an oral dose of 0.5 mg or placebo were investigated in six male Japanese students in a double-blind, crossover design. The peak latencies of PPR showed a statistically significant prolongation, with maximum level at 3h after administration, which recovered to the initial level within 4h. The amplitude of PPR failed to show a definite response to the drug. The serum concentration of ID-540 reached a peak level 2–3h after administration, and then decreased at 4h. N-Desmethyl-ID-540 exhibited a slow, gradual rise in serum. The latencies of PPR were positively correlated with the serum level of ID-540 but not with the N-desmethyl-ID-540. It is concluded that the PPR test may be a useful method for predicting the clinical effects of psychotropic drugs.
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Asami, Y., Otsuka, M., Hirohashi, T., Inaba, S., Yamamoto, H.: The synthesis and pharmacology of a novel benzodiazepine derivative, 1-methyl-5-(2-fluorophenyl)-7-chloro-1 · 3-dihydro-2H-1·4-benzodiazepin-2-one (ID-540). Arzneimittel-Forsch. 24, 1563–1568 (1974)
Inanaga, K., Yamamoto, Y., Ishikawa, K.: Study of the averaged photopalpebral reflex in man. Folia Psychiatr. Neurol. Jpn. 25, 51–67 (1971)
Itil, M.: Quantitative pharmaco-EEG. A new approach to the discovery of a psychotropic drug. In: Psychopharmacology, sexual disorders and drug abuse, T. A. Ban, J. R. Boissier, G. J. Gessa, H. Heimann, L. Hollister, H. E. Lehman, I. Munkvad, Hannah Setinberg, F. Sulser, A. Sundwall, and O. Vinař, eds., pp. 13–30. Amsterdam-London: North-Holland 1973
Miura, T.: Application of photopalpebral reflex for stomatology. Pain and photopalpebral reflex. J. Jpn. Stomatol. Soc. 20, 52–68 (1971)
Ogawa, H., Nanba, M., Yamasaki, K., Watanabe, H.: Clinical evaluation of flurazepam and nitrazepam as preanesthetic medicament. Pharmacol. Treat. 2, 1537–1548 (1974)
Sato, J., Tanaka, M., Isozaki, H., Inanaga, K.: Physiological study of the averaged photopalpebral reflex in man. Jpn. J. EEG EMG 3, 258–265 (1975)
Sato, J.: Physiological study of the averaged photopalpebral reflex in man. J. Kurume Med. Assoc. 39, 1180–1191 (1976)
Tachibana, N., Kawaguchi, T., Minobe, T., Mizota, H., Inoue, S., Yamamura, H.: Effect of flurazepam on a preanesthetic night sleep. Med. Prog. 87, 640–654 (1973)
Tanaka, M., Hirai, T., Inanaga, K., Isozaki, H.: The effect of flurazepam on the photopalpebral reflex. Clin. Psychiatry 16, 193–202 (1974a)
Tanaka, M., Sato, J., Isozaki, H., Inanaga, K.: Application of photopalpebral reflex for clinical pharmacology. Jpn. J. Clin. Pharmacol. 5, 345–347 (1974b)
Tanaka, M., Sato, J., Isozaki, H., Inanaga, K.: The level of consciousness and photopalpebral reflex. Jpn. J. EEG EMG 2, 281 (1974c)
Tanaka, M., Isozaki, H., Inanaga, K.: Effects of ID-540 on averaged photopalpebral reflex in man. Jpn. J. Pharmacol. 27, 517–522 (1977)
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Tanaka, M., Isozaki, H., Inanaga, K. et al. The effects of a new benzodiazepine derivative, ID-540, on the averaged photopalpebral reflex in man. Psychopharmacology 58, 217–222 (1978). https://doi.org/10.1007/BF00427382
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DOI: https://doi.org/10.1007/BF00427382