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Effects of zimelidine, a selective 5-HT uptake inhibitor, on serum prolactin levels in man

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Abstract

The levels of serum prolactin were studied both after an acute intake of zimelidine and during a treatment period of 3–7 weeks. No significant changes in basal serum prolactin levels were seen after single oral doses of zimelidine (100 mg) in healthy volunteers during an investigation period of 12 h. Serum prolactin concentrations remained well within the pretreatment levels also during a continuous treatment of depressive patients with zimelidine up to 150 mg orally b.i.d. It is concluded that clinical doses of the selective 5-HT uptake inhibitor zimelidine does not exert any significant effect on serum prolactin levels.

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Authors and Affiliations

  1. Medical Department, Astra Läkemedel AB, S-151 85, Södertälje, Sweden

    E. Syvälahti

  2. Psychiatric Clinic II, Lillhagen Hospital, Gothenburg, Sweden

    A. Nagy

  3. Department of Psychiatry, University Hospital, Utrecht, The Netherlands

    H. M. van Praag

Authors
  1. E. Syvälahti
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  2. A. Nagy
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  3. H. M. van Praag
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Syvälahti, E., Nagy, A. & van Praag, H.M. Effects of zimelidine, a selective 5-HT uptake inhibitor, on serum prolactin levels in man. Psychopharmacology 64, 251–253 (1979). https://doi.org/10.1007/BF00427506

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  • DOI: https://doi.org/10.1007/BF00427506

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