Abstract
The behavioral effects following IP injection of kainic acid in rats could be cancelled with hypobaric hypoxia (8% O2 corresponding to 7000 m altitude) or with IP injections of 7-amino-hex-5-enoic acid at a dose of 0.9 g/kg-1. This protection may result from increased accumulations of GABA in brain tissues.
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Lenicque, P.M., Wepierre, J. & Cohen, Y. Protection by 4-amino-hex-5-enoic acid (γ-vinyl GABA) and hypobaric hypoxia against kainic acid neurotoxicity. Psychopharmacology 66, 51–53 (1979). https://doi.org/10.1007/BF00431989
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DOI: https://doi.org/10.1007/BF00431989