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Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat

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Abstract

Pretreatment with GABA (250–1,000 mg/kg, IP) potentiated the cataleptogenic effect of haloperidol in a dose-dependent manner in rats. GABA (GABA, B.D.H. Ltd.) alone in a dose of 2,000 mg/kg (IP) also induced catalepsy. The results may be due to partial access of blood-borne GABA to the CNS, leading to inhibition of nigro-striatal dopaminergic neurons involved in the functioning of the corpus striatum.

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Authors and Affiliations

  1. Department of Pharmacology, V. M. Medical College, 413003, Solapur, (Maharashtra), India

    J. J. Balsara, J. H. Jadhav & A. G. Chandorkar

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  1. J. J. Balsara
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  2. J. H. Jadhav
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  3. A. G. Chandorkar
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Balsara, J.J., Jadhav, J.H. & Chandorkar, A.G. Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat. Psychopharmacology 68, 105–107 (1980). https://doi.org/10.1007/BF00426658

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  • DOI: https://doi.org/10.1007/BF00426658

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