Abstract
Concentrations of endogenous norepinephrine, dopamine and epinephrine in cerebroventricular perfusates were used to evaluate the effects of drugs on the availability of extracellular catecholamines in the intact rat brain. Administration of the antidepressant drugs imipramine, desmethylimipramine or tranylcypromine resulted in marked increases of both norepinephrine and dopamine concentrations while epinephrine levels were not affected. Treatment with a similar dose of carbamazepine — an anticonvulsant drug with antidepressant activity — resulted in a significant increase in dopamine concentrations without apparent effect on either norepinephrine or epinephrine. It is suggested that at the applied dose, carbamazepine may act to modify the uptake, release or metabolism of dopamine in brain areas adjacent to the cerebroventricular space without affecting the other catecholamines.
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References
Arnold EB, Molinoff PB, Rutledge CO (1977) The release of endogenous norepinephrine and dopamine from cerebral cortex by amphetamine. J Pharmacol Exp Ther 202:554–557
Barkai AI (1981) Myo-Inositol turnover in the intact rat brain: Increased production after d-amphetamine. J Neurochem 36:1485–1491
Ballenger JC, Post RM (1978) Therapeutic effects of carbamazepine in affective illness: a preliminary report. Commun Psychopharmacol 2:159–175
Bartholini G, Stadler H, Gadea Ciria M, Llord KG (1976) The use of the push-pull cannula to estimate the dynamics of acetylcholine and catecholamines within varios brain areas. Neuropharmacology 15:515–519
Blom S (1962) Trigeminal neuralgia: its treatment with a new anticonvulsant drug (G-32883). Lancet i:839–840
Chatterway FD (1931) Acetylation in aqueous alkaline solutions. J Chem Soc 2:2495–2496
Chevillard C, Duchene N, Pasquier R, Alexander JM (1979) Relation of the centrally evoked pressor effect of angiotensin II to central noradrenalin in the rabbit. Eur J Pharmacol 58:203–206
Dembiec D, Cohen G (1981) Potassium induced release of [3H] catecholamine from brain: effects of pre-exposure to catecholamine uptake inhibitors. J Pharmacol Exp Ther 217:727–732
Ecceleston D, Ashcroft GW, Moir ATB, Parker-Rhodes A, Lutz W, O'Mahoney DP (1968) A comparison of 5-hydroxyindoles in various regions of dog brain and cerebrospinal fluid. J Neurochem 15:947–957
Elchisak MA, Powers KH, Ebert MH (1982) Demonstration of conjugated dopamine in monkey CSF chromatography-mass spectrometry. J Neurochem 39:726–728
Fuxe K, Ungerstedt U (1968) Histochemical studies on the effect of (+) amphetamine, drugs of the imipramine group and tryptamine on cerebral intraventricular injection of catecholamines and 5-hydroxytryptamine. Eur J Pharmacol 4:135–144
Guldberg HC, Yates CM (1969) Effects of chlorpromazine on the metabolism of catecholamines in the dog brain. Br J Pharmacol 36:535–541
Horn AS, Coyle JR, Snyder SH (1971): Catecholamine uptake by synaptosomes from rat brain: structural-activity relationship of drugs with differential effects on dopamine and norepinephrine neurons. Mol Pharmacol 7:66–80
Koe BK (1976) Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of the rat brain. J Pharmacol Exp Ther 199:649–661
Klaniecki TS, Corder CN, McDonald RH, Feldman JA (1977) High-performance liquid chromatograhic radio-enzymatic assay for plasma catecholamines. J Lab Clin Med 90:604–612
Kruk ZL, Pycock CJ (1979). Neurotransmitters and drugs. University Park Press, Baltimore
Levitt M, Kowalik S, Barkai AI (1983) Apparent turnover of norepinephrine in the intact rat brain estimated from its rate of appearance in the cerebroventricular compartment. J Neurosc Res 10:93–99
Loullis CC, Hingtgen JN, Shea PA, Aprison MH (1980) In vivo determination of endogenous biogenic amines in rat brain using HPLC and push-pull cannula. Pharmacol Biochem Behavior 12:959–963
Okuma T, Kishimoto A, Inoue K, Matsumoto H, Ogura A, Matsushita T, Nakao T, Ogura C (1973) Anti-manic and prophylactic effects of carbamazepine (Tegretol) on manic depressive psychosis. Folia Psychiatr Neurol Jpn 27:283–297
Parnas J, Gram L, Flachs H (1980) Psychopharmacological aspects of antiepileptic treatment. In: Progress in neurobiology, vol 15:pp 119–138
Philips SR, Robson AM, Boulton AA (1982) Unstimulated and amphetamine stimulated release of endogenous noradrenaline and dopamine from rat brain in vivo. J Neurochem 38:106–111
Post RM, Ballenger JC, Reus VI, Lake CR, Lerner R, Bunney WE Jr (1978) Effects of carbamazepine in mania and depression. Presented at the annual meeting of the American Psychiatry Association, Atlanta, GA. New Research Abstracts 7.
Post RM, Ballenger JC, Uhde TW, Smith T, Rubinow DR, Bunney WE (1982) Effect of carbamazepine on cyclic nucleotides in CSF of patients with affective illness. Biol Psychol 17:1037–1045
Purdy RE, Julien RM, Fairhurst AS, Terry MD (1977) Effect of carbamazepine on the in vitro uptake and release of norepinephrine in adrenergic nerves of rabbit aorta and in whole brain synaptosomes. Epilepsia 18:251–257
Ross SB (1982) The characteristics of serotonin uptake systems. In: Osborne NN (ed) Biology of serotonergic transmission. John Wiley and Sons, New York
Schildkraut JJ (1970) Tranylcypromine: effects on norepinephrine metabolism in rat brain. Am J Psychiatry 126:925–931
Sulser F (1978) Tricyclic antidepressants: animal pharmacology In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol. 14. Plenum Press, New York, pp 157–197
Sulser F, Sanders-Bush E (1971) Effect of drugs on amines in the CNS. Annu Rev Pharmacol II:209–230
Tyce GM, Sharpless NS, Kerr FWL, Nuenter MD (1980) Dopamine conjugates in cerebrospinal fluid. J Neurochem 34:210–212
Westerink NHC, Lejeune B, Korf J, Van Praag HM (1977) On the significance of regional dopamine metabolism in the rat brain for the classification of centrally acting drugs. Eur J Pharmacol 42:179–190
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Kowalik, S., Levitt, M. & Barkai, A.I. Effects of carbamazepine and anti-depressant drugs on endogenous catecholamine levels in the cerebroventricular compartment of the rat. Psychopharmacology 83, 169–171 (1984). https://doi.org/10.1007/BF00429729
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DOI: https://doi.org/10.1007/BF00429729