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Long-lasting tolerance to stimulatory effects of perinatal caffeine treatment

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Abstract

Pregnant rats were treated with caffeine in their drinking water at doses of 136.3 mg/kg/day during gestation and 222.2 mg/kg/day during lactation. The resulting off-spring at 60 days of age (40 days after drug withdrawal) were tested in an activity monitor cage. Spontaneous locomotor activity and that induced by caffeine (10, 30, 60 mg/kg/day) were observed. Treated rats showed apparent tolerance to caffeine-induced motility. Therefore perinatal caffeine treatment seems to induce long-lasting tolerance. This finding contrasts with those previously reported for chronic caffeine treatment in adult rats, where tolerance disappears after only 2–3 weeks following drug with-drawal.

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Authors and Affiliations

  1. Institute of Pharmacology and Pharmacognosy, University of Urbino, Via S. Chiara, 27, Urbino, Italy

    G. Lombardelli, W. Balduini, A. Feduzi, G. Peruzzi & F. Cattabeni

Authors
  1. G. Lombardelli
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  2. W. Balduini
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  3. A. Feduzi
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  4. G. Peruzzi
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  5. F. Cattabeni
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Lombardelli, G., Balduini, W., Feduzi, A. et al. Long-lasting tolerance to stimulatory effects of perinatal caffeine treatment. Psychopharmacology 84, 285–286 (1984). https://doi.org/10.1007/BF00427461

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  • DOI: https://doi.org/10.1007/BF00427461

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