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Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat

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Abstract

Administration of haloperidol (1.4–1.6 mg/kg/day) for up to 12 months or sulpiride (102–109 mg/kg/day) for between 6 and 12 months increased the frequency of purposeless chewing jaw movements in rats. N,n-propylnorapomorphine (NPA) (0.25–2.0 mg/kg SC) did not induce hypoactivity in haloperidol-treated rats at any time; sulpiride treatment for 9 and 12 months caused a reduction in the ability of NPA to induce hypoactivity. Haloperidol, but not sulpiride, treatment enduringly inhibited low dose apomorphine effects (0.125 mg/kg SC). After 12 months, sterotypy induced by high doses of apomorphine (0.5–1.0 mg/kg) was exaggerated in haloperidol-, but not sulpiride-treated rats.

Bmax for specific striatal 3H-spiperone binding was increased by haloperidol, but not sulpiride, treatment throughout the study. Bmax for 3H-NPA binding was elevated only after 12 months of both haloperidol and sulpiride treatment. Bmax for 3H-piflutixol binding was not alfered by chronic haloperidol or sulpiride treatment. Striatal dopamine-stimulated adenylate cyclase activity was inhibited for the 1st month of haloperidol treatment, thereafter returning to control levels; dopamine stimulation was increased after 12 months of sulpiride treatment. Striatal acetylcholine content was increased after 3 and 12 months of treatment with haloperidol, but was not affected by sulpiride.

Chronic administration of sulpiride does not induce identical changes in striatal dopamine function to those caused by haloperidol.

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Authors and Affiliations

  1. MCR Movement Disorders Research Group, University Department of Neurology, and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, SE5 8AF, London, UK

    N. M. J. Rupniak, M. D. Hall, S. Fleminger, G. Kilpatrick, P. Jenner & C. D. Marsden

  2. Institute of Animal Physiology, Agricultural Research Council, Babraham, CB2 4AT, Cambridge, UK

    S. Mann

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  1. N. M. J. Rupniak
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  2. S. Mann
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  3. M. D. Hall
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  4. S. Fleminger
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  5. G. Kilpatrick
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  6. P. Jenner
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  7. C. D. Marsden
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Rupniak, N.M.J., Mann, S., Hall, M.D. et al. Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat. Psychopharmacology 84, 503–511 (1984). https://doi.org/10.1007/BF00431457

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  • DOI: https://doi.org/10.1007/BF00431457

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