Skip to main content
Log in

Dorsal bundle lesions do not affect latent inhibition of conditioned suppression

  • Original Investigations
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Three expreiments are reported which examine the effects of lesions of the dorsal ascending noradrenergic bundle (DB) on latent inhibition using a conditioned suppression procedure in rats. In none of the experiments did the DB lesion have any effect, despite changes in the extent of latent inhibition and in the control procedures used to assess it. The results are discussed in relation to the attentional theory of DB function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ackil JE, Mellgren RL, Halgren C, Frommer GP (1969) Effect of CS preexposure on avoidance learning in rats with hippocampal lesions. J Comp Physiol Psychol 69:739–747

    Google Scholar 

  • Blakeley AGH, Dearnaley DP, Harrison V (1970) The noradrenaline content of the vas deferens of the guinea-pig. Proc R Soc Lond [Biol] 174:491–502

    Google Scholar 

  • Jonsson G, Hallman H, Ponzio F, Ross SB (1981) DSP4 (N-2-cloroethyl-N-ethyl-bromobenzylamine) — A useful denervation tool for central and peripheral noradrenaline neurons. Eur J Pharmacol 72:173–188

    Google Scholar 

  • Lorden JF, Rickert EJ, Berry DW (1983) Forebrain monoamines and associative learning: 1. Latent inhibition and conditioned inhibition. Behav Brain Res 9:181–199

    Google Scholar 

  • Lorden JF, Rickert EJ, Dawson R, Pelleymounter MA (1980) Forebrain norepinephrine and the selective processing of information. Brain Res 190:569–573

    Google Scholar 

  • Lubow RE (1973) Latent inhibition. Psychol Bull 79:398–407

    Google Scholar 

  • Lubow RE, Schnur P, Rifkin B (1976) Latent inhibition and conditioned attention theory. J Exp Psychol [Anim Behav] 2:163–174

    Google Scholar 

  • Mackintosh NJ (1983) Conditioning and associative learning. Oxford University Press, New York

    Google Scholar 

  • Mason ST (1980) Noradrenaline and selective attention: a review of the model and the evidence. Life Sci 27:617–631

    Google Scholar 

  • Mason ST (1981) Noradrenaline in the brain: progress in theories of behavioural function. Prog Neurobiol 16:263–303

    Google Scholar 

  • Mason ST, Iversen SD (1979) Theories of the dorsal bundle extinction effect. Brain Res Rev 1:107–137

    Google Scholar 

  • Mason ST, Lin D (1980) Noradrenaline and selective attention in the rat. J Comp Physiol Psychol 94:819–832

    Google Scholar 

  • McFarland DJ, Kostas J, Drew WG (1978) Dorsal hippocampal lesions: Effects of preconditioning CS exposure on flavor aversion. Behav Biol 22:398–404

    Google Scholar 

  • Millenson JR (1975) Systems developments in the ACT language: Towards machine independence. Behav Res Methods and Instrumentation 7:165–173

    Google Scholar 

  • Mohammed AK, Everitt BJ, Dunn LT, Robbins TW, Kilbourn A, Archer T (1983) Noradrenaline and the latent inhibition effect in rats. 5th Catecholamine Symposium, Goteburg, Abstract 338. In: Supplement to Prog Neuropsychopharmacol Biol Psychiatr

  • Robbins TW, Everitt BJ, Fray PJ, Gaskin M, Carli M, de la Riva C (1982) The roles of the central catecholamines in attention and learning. In: Spiegelstein MY, Levy A (eds) Behavioral models and the analysis of drug action. Proceedings of the 27th OHOLO conference, Elsevier, Amsterdam pp 109–134

    Google Scholar 

  • Solomon PR, Moore JW (1975) Latent inhibition and stimulus generalisation of the classically-conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following dorsal hippocampal ablation. J Comp Physiol Psychol 89:1192–1203

    Google Scholar 

  • Tsaltas E (1983) The role of the dorsal noradrenergic bundle in anxiety and selective attention. D. Phil. thesis, University of Oxford

  • Tsaltas E, Preston GC, Gray JA (1983) The effects of dorsal bundle lesions on serial and trace conditioning. Behav Brain Res 10:361–374

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tsaltas, E., Preston, G.C., Rawlins, J.N.P. et al. Dorsal bundle lesions do not affect latent inhibition of conditioned suppression. Psychopharmacology 84, 549–555 (1984). https://doi.org/10.1007/BF00431465

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00431465

Key words

Navigation