Abstract
Leu- and Metenkephalin (Lenk and Menk) and their more stable analogues d-Ala-Leu- and d-Ala-Meten-kephalin (DALenk and DAMenk) as well as d-ala-d-Leu-and d-Ala-d-Metenkephalin (DADLenk and DADMenk) were infused bilaterally into substantia nigra in awake rats and oral movements were recorded for 90 min. DADLenk and DADMenk elicited dose-dependent biting dyskinesias with a chewing rate of about 90 jaw movements/min. DALenk produced a similar but weaker effect, whereas DAMenk, Lenk and Menk were ineffective in the doses given. These findings suggest a possible enkephalinergic mechanism underlying neuroleptic-induced tardive dyskinesias.
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Liminga, U., Johansson, P., Nylander, I. et al. Intranigral infusion of enkephalins elicits dyskinetic biting in rats. Psychopharmacology 99, 299–303 (1989). https://doi.org/10.1007/BF00445547
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DOI: https://doi.org/10.1007/BF00445547