Abstract
The effect of intra-accumbens injections of various dopaminergic agonists and antagonists on the rat locomotor activity has been evaluated in automated open fields. Locomotor stimulation has been observed after local administration ofd-amphetamine (10 μg), apomorphine (10 μg), as well as of solution containing the D1 agonist SKF 38 393 and D2 receptor agonist LY 171 555 (quinpirole) in doses (10 and 4 μg, respectively) which were inactive when both drugs were administered separately. On the other hand separate injections of metoclopramide (0.1 μg) and SCH 23 390 (0.5 μg) (D2 and D1 receptor antagonists) very potently inhibited animals' locomotor activity. The data indicate that concomitant stimulation of both accumbens D1- and D2-receptor related mechanisms is a necessary condition to increase rat motility. Moreover, it seems that accumbens D1 receptors may be differently involved in the control of facilitatory versus inhibitory motor processes.
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References
Andersen PH, Nielsen EB (1986) The dopamine D1 receptor: biochemical and behavioral aspects. In: Breese GR, Creese I (eds) Neurobiology of central D1-dopamine receptors. Plenum Publishing Corporation, New York, pp 73–91
Arnt J (1985a) Hyperactivity induced by stimulation of separate D-1 and D-2 receptors in rats with bilateral 6-OHDA lesions. Life Sci 37:717–723
Arnt J (1985b) Behavioral stimulation induced by separate dopamine D-1 and D-2 receptor sites in reserpine-pretreated but not normal animal. Eur J Pharmacol 113:79–88
Arnt J, Hyttel J, Perregaard A (1987) Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behavior in rats. Eur J Pharmacol 133:137–145
Arnt J, Bogeso KP, Hyttel J, Meier E (1988) Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. Pharmacol Toxicol 62:121–130
Cools RA (1986) Mesolimbic dopamine and its control of locomotor activity in rats: differences in pharmacology and light/dark periodicity between the olfactory tubercle and the nucleus accumbens. Psychopharmacology 88:451–459
Costall B, Naylor R, Cannon JG, Lee T (1977) Differentation of the dopaminergic mechanisms mediating stereotyped behavior and hyperactivity in the nucleus accumbens and caudateputamen. J Pharm Pharmacol 29:337–342
Dall'Olio R, Gandolfi O, Vaccheri A, Roncada P, Montanaro N (1988) Changes in behavioral responses to the combined administration of D1 and D2 dopamine agonists in normaotensive and D1 supersensitive rats. Eur J Pharmacol 95:381–385
Dutere-Boucher D, Ledere JF, Panissaud CH, Costentin J (1988) Acute effects of direct dopamine agonists in the mouse-behavioural despair test. Eur J Pharmacol 154:185–190
Frussa-Filho R, Palermo-Neto J (1988) Effects of single and longterm metoclopramide administration on open field and stereotyped behavior of rats. Eur J Pharmacol 149:323–329
Gandolfi O, Dall'Olio R, Vaccheri A, Romcada P, Montanaro N (1988) Responses to selective D-1 and D-2 agonists after repeated treatment with selective D-1 and D-2 antagonists. Pharmacol Biochem Behav 30:463–469
Hjorth S, Carlsson A (1988) In vivo receptor binding neurochemical and functional studies with the dopamine D-1 receptor antagonists SCH 23 390. J Neural Transm 72:83–97
Jackson DM, Hashizume M (1986) Bromocriptine induces locomotor stimulation in dopamine-depleted mice when D-1 dopamine receptors are stimulated with SKF 38393. Psychopharmacology 90:147–149
Jackson DM, Jenkins DF, Ross SB (1988) The motor effects of bromocriptine — a review. Psychopharmacology 95:433–446
Klemm WR, Block H (1988) D-1 and D-2 receptor blockade have additive cataleptic effects in mice but receptor effects may interact in opposite ways. Pharmacol Biochem Behav 29:223–229
Longoni R, Spina L, Di Chiara G (1987) Permissive role of D-1 receptor stimulation for the expression of D-2 mediated behavioral responses: a quantitative phenomenological study in rats. Life Sci 41:2135–2145
Mogenson GJ, Jones DL, Yiu Yim Chi (1980) From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14:69–97
Pellegrino LJ, Pellegrino AS, Cushman AJ (1967) A stereotaxic atlas of the rat brain. Plenum Press, New York
Plaznik A, Danysz W, Kostowski W (1985) A stimulatory effect of intraaccumbens injections of noradrenaline on the behavior of rats in the forced swim test. Psychopharmacology 87:119–123
Starr MS (1988) D-1/D-2 behavioral interactions in the rat involving striatal dopamine D-1 receptors. Eur J Pharmacol 151:479–482
Vaccheri A, Dall'Orio R, Gandolfi D, Montanaro N (1986) Involvement of different dopamine receptors in rat diphasic motility response to apomorphine. Psychopharmacology 89:265–268
Van Ree JM, Gaffori O, De Wied D (1983) In rats, the behavioral profile of CCK-8 related peptides resembles that of antipsychotic agents. Eur J Pharmacol 93:63–78
Vasse M, Cahgraoni A, Protais Ph (1988) Climbing and stereotyped behavior in mice require the stimulation of D-1 dopamine receptors. Eur J Pharmacol 148:221–229
White FJ, Bednarz LM, Wachtel SR, Hjorth S, Brooderson RJ (1988) Is stimulation of both D-1 and D-2 receptors necessary for the expression of dopamine-mediated behaviors. Pharmacol Biochem Behav 30:189–193
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Plaznik, A., Stefanski, R. & Kostowski, W. Interaction between accumbens D1 and D2 receptors regulating rat locomotor activity. Psychopharmacology 99, 558–562 (1989). https://doi.org/10.1007/BF00589908
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DOI: https://doi.org/10.1007/BF00589908