Summary
Data published in the preceding paper on effects of augmented arterial CO2 tensions on lung ventilation before and after inducing acidosis by NH4Cl or CaCl2 or acetazolamide (diamox) were used to differentiate the partial effects of p H changes at constant CO2 tension and of CO2 tension changes at constant p H in arterial blood on lung ventilation.
The total increase of lung ventilation caused by elevation of CO2 tension was found to be 3.2 l min−1 Torr−1. The partial p H effect was 1.4 l min−1 Torr−1 or 43% per cent of the total effect and the partial CO2 effect was 1.8 l min−1 Torr−1 or 57 per cent of the total effect. This is in agreement with the prediction of Gray and the experimental results of Lambertsen and Semple.
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Literatur
Cunningham, D. J. C., S. Lahiri, B. B. Lloyd and D. G. Shaw: J. Physiol. (Lond.) 148, 71 P (1959).
Domizi, D. B., J. F. Perkins Jr. and J. S. Byrne J. appl. Physiol. 14, 557 (1959).
Gray, J. S.: Pulmonary ventilation and its physiological regulation. Springfield, Ill.: C. C. Thomas 1950.
Lambertsen, C. J., M. G. Smyth, S. J. G. Semple and R. Gelfand: Fed. Proc. 17, 92 (1958).
Loeschcke, H. H., H. P. Koepchen u. K. H. Gertz: Pflügers Arch. ges. Physiol. 266, 569 (1958).
Semple, S. J. G., C. J. Lambertsen, M. G. Smyth and R. Gelfand: Amer. J. med. Sci. 237, 537 (1959).
Shaw, D. G.: Some factors affecting respiration in man. Oxford: Thesis B. Sc. 1959.
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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.
Die Ergebnisse wurden teilweise mitgeteilt in Vorträgen vor der Gesellschaft für Morphologie und Physiologie in München und in Oxford im Juli 1959.
Stipendiat der A. v. Humboldt-Stiftung.
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Loeschcke, H.H., Katsaros, B. & Lerche, D. Differenzierung der Wirkungen von CO2-Druck und Wasserstoffionenkonzentration im Blut auf die Atmung beim Menschen. Pflügers Archiv 270, 461–466 (1960). https://doi.org/10.1007/BF00362216
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DOI: https://doi.org/10.1007/BF00362216