Summary
In hydraulic non-occlusive models, mixing effects were studied with slug-injection and constant-infusion techniques. Measurements were accomplished by means of catheters specially constructed with thermistors. Constant-rate infusion of 5 ml/min of saline at room temperature showed homogeneity of mixing. Good correlation (r=0.936) was found between metered flow ranging from 50–450 ml/min and reciprocal temperature changes.
In anesthetized open chest dogs reciprocal temperature changes during constant-infusion thermodilution was compared with coronary sinus flow metered by graduated cylinder and stop-watch. For this purpose all the coronary sinus blood was directed through a tubing system with a Y-connector into the jugular vein. In the range of 50–450 ml/min the metered coronary sinus blood flow and the reciprocal of the observed changes in temperature showed a linear correlation (r=0.949). The reproducibility of the thermodilution method is fairly good. Therefore it is believed that this technique will allow accurate measurement of coronary sinus blood flow.
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This work was supported by a grant of the Swiss National Fund for Scientific Research.
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Hirzel, H.O., Amende, I., Schriber, K. et al. Evaluation of the thermodilution technique for measuring coronary sinus blood flow. Pflugers Arch. 330, 257–264 (1971). https://doi.org/10.1007/BF00588616
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DOI: https://doi.org/10.1007/BF00588616