Summary
In an attempt to identify the secretory mechanism of pancreatic γ-glutamyl transpeptidase (γ-GTP), constant intravenous infusions of secretin alone and in combination with caerulein were performed in anesthetized dogs prepared with a pancreatic fistula. Caerulein produced a marked increase in amylase concentration and only a slight increase in γ-GTP. γ-GTP concentration of the pancreatic juice varied from 12 to 490 mU per ml which ranged up to 188-fold higher than that of the serum. The enzyme concentration depended largely on the flow rate, revealing 3 characteristic curvlinear relationship, regardless of whether caerulein was added to the secretin infusion. No significant relation was demonstrated between amylase concentration and flow rate, amylase and γ-GTP concentrations, and γ-GTP and protein concentration. An inverse linear correlation between γ-GTP and chloride concentrations was obtained when flow rate was below 2.5 ml per 15 min. A significant linear relationship was demonstrated between γ-GTP and leucine aminopeptidase concentrations, and amylase and protein concentrations. The results presented clearly demonstrate that the mechanism of pancreatic secretion of γ-GTP is quite distinct from that of amylase.
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Supported in part by Cancer Research Grant from the Welfare Ministry of Japan.
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Nakajima, S., Toda, Y., Hayakawa, T. et al. Secretory characteristics of pancreatic γ-glutamyl transpeptidase. Pflugers Arch. 345, 271–279 (1973). https://doi.org/10.1007/BF00585846
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DOI: https://doi.org/10.1007/BF00585846