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New type of matrix for matrix-assisted laser desorption mass spectrometry of polysaccharides and proteins

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Abstract

3-Aminoquinoline is introduced as matrix for matrix-assisted laser desorption mass spectrometry of polysaccharides and proteins. The first MALD mass spectrum of the polysaccharide inulin is reported. 3-Aminoquinoline seems to be more effective than the commonly used acidic matrix 2,5-dihydroxybenzoic acid, assisting in the desorption and ionisation of inulin. A higher sensitivity, sharper peaks and a lower background were observed. 3-Aminoquinoline is also quite effective when measuring the protein myoglobin.

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Authors and Affiliations

  1. Department of Chemistry, Carl von Ossietzky-Universität, Postfach 2503, D-26111, Oldenburg, Germany

    Jürgen O. Metzger & Ralf Woisch

  2. Department of Physics, Carl von Ossietzky-Universität, Postfach 2503, D-26111, Oldenburg, Germany

    Wilfried Tuszynski & Raimond Angermann

Authors
  1. Jürgen O. Metzger
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  2. Ralf Woisch
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  3. Wilfried Tuszynski
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  4. Raimond Angermann
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Metzger, J.O., Woisch, R., Tuszynski, W. et al. New type of matrix for matrix-assisted laser desorption mass spectrometry of polysaccharides and proteins. Fresenius J Anal Chem 349, 473–474 (1994). https://doi.org/10.1007/BF00322937

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  • DOI: https://doi.org/10.1007/BF00322937

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