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Estimation of the uncertainty of CRMs in accordance with GUM: Application to the certification of four enzyme CRMs

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Abstract

Uncertainties of four enzyme-CRMs that have recently been certified in a co-operation between the IRMM and the International Federation for Clinical Chemistry were estimated. Estimation was based on the sum of the uncertainties of characterization, homogeneity and stability. Data from the certification collaborative study were used to estimate laboratory uncertainties, which form the basis for the uncertainty of characterization. Estimations for the uncertainty of homogeneity were derived from classical homogeneity studies. The estimations of uncertainty of stability caused the most difficulties. Realistic uncertainties fitting the needs of customers while being derived from measurement data based on theoretical considerations were obtained.

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Authors and Affiliations

  1. European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), 2440 Geel, Belgium e-mail: jean.pauwels@irmm.jrc.be, , , , , , BE

    T. P. J. Linsinger, J. Pauwels, H. Schimmel & A. Lamberty

  2. Nederlands Meetinstituut (NMi), Schoemakerstraat 97, 2600 AR Delft, The Netherlands, , , , , , NL

    A. M. H. van der Veen

  3. Medizinische Hochschule Hannover, Institut für Klinische Chemie, MHH OE-8110, 30623 Hannover, Germany, , , , , , DE

    G. Schumann

  4. Institut für Klinische Biochemie, Universität Bonn, 53217 Bonn, Germany, , , , , , DE

    L. Siekmann

Authors
  1. T. P. J. Linsinger
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  2. J. Pauwels
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  3. H. Schimmel
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  4. A. Lamberty
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  5. A. M. H. van der Veen
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  6. G. Schumann
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  7. L. Siekmann
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Additional information

Received: 11 May 2000 / Revised: 21 June 2000 / Accepted: 27 June 2000

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Linsinger, T., Pauwels, J., Schimmel, H. et al. Estimation of the uncertainty of CRMs in accordance with GUM: Application to the certification of four enzyme CRMs. Fresenius J Anal Chem 368, 589–594 (2000). https://doi.org/10.1007/s002160000547

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  • DOI: https://doi.org/10.1007/s002160000547

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