Skip to main content
SpringerLink
Log in

Electrophysiological analysis of the hippocampal-septal projections: I. Response and topographical characteristics

  • Published:
Experimental Brain Research Aims and scope Submit manuscript

Summary

The hippocampal input to the septal region was studied, in rats, by electrophysiological methods. The major observations were: 1. the hippocampal fibers are excitatory with respect to their target cells in the lateral septal nucleus (LSN); 2. the distribution of the subcallosal fornix is restricted to the dorsomedial regions of the LSN; 3. the fimbria contains fibers terminating throughout the dorsal aspect of the ipsilateral and contralateral septum; 4. there is an extensive overlapping in the distribution of the ipsi-and contra-lateral fimbria components with convergence upon single septal cells frequently seen; 5. the posterior part of hippocampal region CA1 contributes fibers to the fimbria as well as to the fornix.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ACB:

Bed nucleus of the anterior commissure

AP Ref 0:

The anterior-posterior and midline reference zero

CA:

Anterior commissure

CC:

Corpus callosum

CCA 3–4:

Contralateral hippocampal fields CA-3–4

Cd Pt:

Caudate putamen complex

CFim:

Contralateral fimbria

CMA:

Corticomedial maygdaloid division

GP:

Globus pallidus

Hipp:

Hippocampus

ICA1 (a):

Anterior part of the ipsilateral hippocampal field CA1

ICA1 (p):

Posterior part of the ipsilateral hippocampal field CA1

ICA3–4:

Ipsilateral hippocampal field CA3–4

IFim:

Ipsilateral fimbria

IFx:

Ipsilateral fornix

LSN:

Lateral septal nucleus

ME:

Microelectrode

MSN:

Medial septal nucleus

POA:

Pre-optic area

References

  • Andersen, P., Bruland, H., Kaada, B.R.: Activation of the field CA1 of the hippocampus by septal stimulation. Acta physiol. scand. 51, 29–40 (1961).

    Google Scholar 

  • Andy, O.F., Stephan, H.: The nuclear configuration of the septum of galago demidovii. J. comp. Neurol. 111, 503–545 (1959).

    Google Scholar 

  • —: Septal nuclei in the Soricidal (Insectivors): cyto-architectonic study. J. comp. Neurol. 117, 251–273 (1961).

    Google Scholar 

  • —: The septum of the cat. Springfield, Ill.: Charles C. Thomas 1964.

    Google Scholar 

  • Bishop, G.H., Clare, M.H.: Sites of origin of electric potentials in striate cortex. J. Neurophysiol. 15, 201–220 (1952).

    Google Scholar 

  • Brady, J.V., Nauta, W.J.H.: Subcortical mechanisms in emotional behavior; effective changes following septal forebrain lesions in the albino rat. J. comp. physiol. Psychol. 46, 339–346 (1954).

    Google Scholar 

  • —: Subcortical mechanisms in emotional behavior; the duration of effective changes following septal and habenular lesions in the albino rat. J. comp. physiol. Psychol. 48, 412–420 (1955).

    Google Scholar 

  • Cajal, 1955. See Bamón y Cajal.

  • Cragg, B.G., Hamlyn, L.H.: Some commissural and septal connexions of the hippocampus in the rabbit. A combined histological and electrical study. J. Physiol. (Lond.) 135, 460–485 (1957).

    Google Scholar 

  • Daitz, H.M., Powell, T.P.S.: Studies of the connexions of the fornix system. J. Neurol. Neurosurg. Psychiat. 17, 75–82 (1954).

    Google Scholar 

  • DeFrance, J.F., Shimono, T., Kitai, S.T.: Anatomical distribution of the hippocampal fibers afferent to the lateral septal nucleus. Brain Res. 34, 176–180 (1971).

    Google Scholar 

  • —: Hippocampal inputs to the lateral septal nucleus: patterns of facilitation and inhibition. Brain Res. 37, 333–339 (1972).

    Google Scholar 

  • —, Kitai, S.T., Shimono, T.: Electrophysiological analysis of the hippocampal-septal projections. II. Functional characteristics. Exp. Brain Res. 17, 463–476 (1973).

    Google Scholar 

  • Eccles, J.C., Sasaki, K., Strata, P.: Interpretation of the potential field generated in the cerebellar cortex by a mossy fiber valley. Exp. Brain Res. 3, 58–80 (1967).

    Google Scholar 

  • Fox, C.A.: Certain basal teleneephalic centers in the cat. J. comp. Neurol. 72, 1–62 (1940).

    Google Scholar 

  • Gloor, P., Vera, C.L., Sperti, L.: Electrophysiological studies of hippocampal neurons. I. Configuration and laminar analysis of the “resting” potential gradient, of the maintransient response to perforant path fimbrial and mossy fiber valleys and of “spontaneous” activity. E.E.G. clin. Neurophysiol. 15, 353–378 (1963).

    Google Scholar 

  • Guillery, R.W.: Degeneration in the hypothalamic connexions of the albino rat. J. Anat. (Lond.) 91, 91–115 (1957).

    Google Scholar 

  • Hess, W.R.: The functional organization of the diencephalon. New York: Gunne and Stratton 1957.

    Google Scholar 

  • Jeserick, N.W.: The nuclear pattern and the fiber connections of certain non-cortical areas of the telencephalon of the mink (mustela vision). J. comp. Neurol. 83, 173–211 (1945).

    Google Scholar 

  • Johnson, T.N.: An experimental study of the fornix and hypothalamo-segmental tracts in the oat. J. comp. Neurol. 125, 29–40 (1965).

    Google Scholar 

  • Kenyon, J.: The effects of septal lesions upon motivated behavior in the rat. Ph.D. Dissertation, McGill University 1962.

  • Lauer, E.W.: The nuclear pattern and fiber connections of certain basal teleneephalic centers in the macaque. J. comp. Neurol. 82, 215–254 (1945).

    Google Scholar 

  • —: Certain olfactory centers of the forebrain of the giant panda (ailuropoda melinoleuca). J. comp. Neurol. 90, 213–241 (1949).

    Google Scholar 

  • McCleary, B.A.: Response specificity in the behavioral effects of limbic lesions in the cat. J. comp. physiol. Psychol. 54, 605–613 (1961).

    Google Scholar 

  • McLardy, T.: Observations on the fornix of the monkey. I. Cell studies. J. comp. Neurol. 103, 305–326 (1955).

    Google Scholar 

  • —: Observations on the fornix of the monkey. II. Fiber studies. J. comp. Neurol. 103, 327–344 (1955).

    Google Scholar 

  • Nauta, W.J.H.: An experimental study of the fornix system in the rat. J. comp. Neurol. 104, 247–271 (1956).

    Google Scholar 

  • Pellegrino, L.J., Cushman, A.J.: A sterotaxic atlas of the rat brain. New York: Apple ton Century-Crofts 1967.

    Google Scholar 

  • Powell, T.P.S., Cowan, W.M.: An experimental study of the efferent connexions of the hippocampus. Brain 78, 115–132 (1955).

    Google Scholar 

  • Raisman, G.: The connexions of the septum. Brain 89, 317–348 (1966).

    Google Scholar 

  • —: A comparison of the mode of termination of the hippocampal and hypothalamic efferents to the septal nuclei as revealed by electron microscopy of degeneration. Exp. Brain Res. 7, 317–343 (1969).

    Google Scholar 

  • —, Cowan, W.M., Powell, T.P.S.: An experimental analysis of the efferent projections of the hippocampus. Brain 89, 83–108 (1966).

    Google Scholar 

  • Rall, W.: Distinguishing theoretical synaptic potentials computed for different soma-dendritic distribution of synaptic input. J. Neurophysiol. 30, 1138–1168 (1967).

    Google Scholar 

  • —, Burke, R.E., Smith, T.G., Nelson, P.G., Frank, K.: Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. J. Neurophysiol. 30, 169–193 (1967).

    Google Scholar 

  • Ramón y Cajal, S.: Studies on the cerebral cortex. Translated by Kraft, pp. 135–163. Chicago: The Year Book Publishers 1955.

    Google Scholar 

  • Siegel, A., Tassoni, J.P.: Differential efferent projections from the ventral and dorsal hippocampus of the cat. Brain Behav. Evol. 4, 185–200 (1971a).

    Google Scholar 

  • Valverde, F.: Studies on the forebrain of the mouse. J. Anat. (Lond.) 97, 157–180 (1963).

    Google Scholar 

  • Young, M.W.: The nuclear pattern and fiber connections of the non-cortical centers of the telencephalon of the rabbit. J. comp. Neurol. 65, 295–401 (1936).

    Google Scholar 

Download references

Author information

Author notes

  1. T. Shimono

    Present address: Institute for Brain Research, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan

Authors and Affiliations

  1. Morin Memorial Laboratory, Department of Anatomy, Department of Psychology, Wayne State University, Detroit, USA

    J. F. DeFrance, S. T. Kitai & T. Shimono

Authors
  1. J. F. DeFrance
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. T. Kitai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Shimono
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by U.S. Public Health Service Grants RR 5384 and NB 00405.

Rights and permissions

Reprints and permissions

About this article

Cite this article

DeFrance, J.F., Kitai, S.T. & Shimono, T. Electrophysiological analysis of the hippocampal-septal projections: I. Response and topographical characteristics. Exp Brain Res 17, 447–462 (1973). https://doi.org/10.1007/BF00234861

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00234861

Key words

Search

Navigation