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Types of interneurons and their participation in the neuronal network of the medial geniculate body

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Summary

Three different types of interneurons can be separated in the Golgi picture, and many of their details can be identified under the electron microscope, in the medial geniculate body (MGB) of the cat: (1) typical short axon Golgi II. cells of the thalamic type, (2) somewhat larger Golgi type II cells with medium range axon, and (3) spidery neurogliform short axon cells. The most distinctive features of the two first types (1) and (2) are their irregular drumstick shape appendages, increasing in number as well as in length and irregularity of their stalks towards the periphery of the dendrites. These appendages form the vast majority of synaptic profiles in the aggregations of synaptic neuropil (glomeruli) of the nuclei, and they are both presynaptic and postsynaptic by the usual standards applied for the evaluation of the polarity of synapses. The characteristic beaded dendrites of the (3) neurogliform cell type can be recognised particularly easily in the electron microscope picture. They are both presynaptic and postsynaptic in structural polarity. All identified process profiles of interneurons contain flattened (F.-type) or pleomorphic synaptic vesicles. Membrane contacts, in which the interneurons appear to be presynaptic are either of the symmetric (Gray type II) or of an intermediate type. The membrane contacts of postsynaptic portions of the interneurons are usually of the asymmetric type (Gray type I) and the presynaptic profiles contain round (R-type) vesicles. The larger one have been shown already earlier to be derived from specific sensory (inferior collicular) afferents, while many of the smaller ones could be identified in the present study as being derived from cortico-geniculate descending pathways, arising from the auditory areas. Some of the synaptic contacts of the interneurons are apparently derived from other interneurons, the presynaptic profiles being often equivocal or more likely of axonal origin (all interneurons have clear axons in the Golgi picture). The occurrence of three distinct types of interneurons — probably all of inhibitory nature — the complexity in synaptic arrangement, and more particularly in the dendritic linkage of numerous synaptic sites does not favour such simple explanations as surround inhibition by forward or by backward inhibition, but suggests more sophisticated modes of impulse processing in the MGB.

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References

  • Aitkin, L.M.: Medial geniculate body of the cat: responses to tonal stimuli of neurons in medial division. J. Neurophysiol. 36, 275–283 (1973)

    Google Scholar 

  • Aitkin, L.M., Dunlop, C.W.: Inhibition in the medial geniculate body of the cat. Exp. Brain Res. 7, 68–83 (1969)

    Google Scholar 

  • Andersen, P., Eccles, J.C., Sears, T.A.: The ventro-basal complex of the thalamus: types of cells, their responses and functional organization. J. Physiol. (Lond.) 174, 370–399 (1964)

    Google Scholar 

  • Campos-Ortega, J., Glees, P., Neuhoff, V.: Ultrastructural analyses of individual layers in the lateral geniculate body of the monkey. Z. Zellforsch. 87, 82–100 (1968)

    Google Scholar 

  • Diamond, J., Gray, E.G., Yasargil, G.M.: The function of the dendritic spine: an Hypothesis. In: Excitatory synaptic mechanisms. pp. 213–222. (Eds. P. Andersen and J.K.S. Jansen). Fifth International Meeting of Neurobiologists. Sandefjord 1969. Oslo: Universitatsverlaget 1970

    Google Scholar 

  • Dowling, J.E., Boycott, B.B.: Organization of the primate retina. Electron microscopy. Proc. roy. Soc. B 166, 80–111 (1966)

    Google Scholar 

  • Eccles, J.C.: The physiology of synapses. Berlin-Göttingen-Heidelberg-New York: Springer 1964

    Google Scholar 

  • Famiglietti, E.V., Jr.: Dendro-dendritic synapses in the lateral geniculate nucleus of the cat. J. Anat. (Lond.) 102, 189–222 (1970)

    Google Scholar 

  • Famiglietti, E.V., Jr., Peters, V.: The synaptic glomerulus and the intrinsic neuron in the dorsal lateral geniculate nucleus of the cat. J. comp. Neurol. 144, 285–334 (1972)

    Google Scholar 

  • Fink, R.P., Heimer, L.: Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system. Brain Res. 4, 369–374 (1967)

    Google Scholar 

  • Grossman, A., Lieberman, A.R., Webster, K.E.: A Golgi study of the rat dorsal lateral geniculate nucleus. J. comp. Neurol. 150, 441–466 (1973)

    Google Scholar 

  • Guillery, R.W.: A study of Golgi preparations from the dorsal lateral geniculate nucleus of the adult cat. J. comp. Neurol. 128, 21–50 (1966)

    Google Scholar 

  • Harding, B.N.: Dendro-dendritic synapses, including reciprocal synapses in the ventrolateral nucleus of the monkey thalamus. Brain Res. 34, 181–185 (1971)

    Google Scholar 

  • Hinds, J.: Reciprocal and serial dendro-dendritic synapses in the glomerular layer of the rat olfactory bulb. Brain Res. 17, 530–534 (1970)

    Google Scholar 

  • Hull, E.M.: Corticofugal influence in the macaque lateral geniculate nucleus. Vision Res. 8, 1285–1298 (1968)

    Google Scholar 

  • Jones, E.G., Rockel, A.J.: The synaptic organization in the medial geniculate body of afferent fibres ascending from the inferior colliculus. Z. Zellforsch. 113, 44–66 (1971)

    Google Scholar 

  • Kalil, R.E., Chase, R.: Corticofugal influence on activity of lateral geniculate neurons in the cat. J. Neurophysiol. 33, 459–474 (1970)

    Google Scholar 

  • Le Vay, S.: On the neurones and synapses of the lateral geniculate nucleus of the monkey and the effects of eye enucleation. Z. Zellforsch. 113, 396–419 (1971)

    Google Scholar 

  • Lieberman, A.R.: Neurons with presynaptic perikarya and presynaptic dendrites in the rat lateral geniculate nucleus. Brain Res. 59, 35–59 (1973)

    Google Scholar 

  • Lieberman, A.R.: Comments on the fine structural organization of the dorsal lateral geniculate nucleus of the mouse. Z. Anat. Entwickl.-Gesch. 145, 261–268 (1974)

    Google Scholar 

  • Lieberman, A.R., Webster, K.E.: Presynaptic dendrites and distinctive class of synaptic vesicle in the rat dorsal geniculate nucleus. Brain Res. 42, 196–200 (1972)

    Google Scholar 

  • Lund, R.D.: Synaptic patterns of the superficial layers of the superior colliculus. J. comp. Neurol. 135, 179–208 (1969)

    Google Scholar 

  • Majorossy, K., Kiss, A.: Specific patterns of neuron arrangement and of synaptic articulation in the medial geniculate body. Exp. Brain Res. (1976) (in press)

  • Majorossy, K., Réthelyi, M.: Synaptic architecture of the medial geniculate body. (Ventral division). Exp. Brain Res. 6, 306–323 (1968)

    Google Scholar 

  • Morest, D.K.: The lateral tegmental system of the midbrain and the medial geniculate body: study with Golgi and Nauta methods in cat. J. Anat. (Lond.) 99, 611–634 (1965)

    Google Scholar 

  • Morest, D.K.: Dendro-dendritic synapses of cells that have axons: the fine structure of Golgi type II cell in the medial geniculate body of the cat. Z. Anat. Entwickl.-Gesch. 133, 216–246 (1971)

    Google Scholar 

  • Morest, D.K.: Synaptic relationships of Golgi type II cells in the medial geniculate body of the cat. J. comp. Neurol. 162 157–194 (1975)

    Google Scholar 

  • Nelson, P.G., Erulkar, S.D.: Orthodromically produced changes in motoneuronal extracellular fields. J. Neurophysiol. 27, 928–941 (1964)

    Google Scholar 

  • Pasik, P., Pasik, T., Hámori, J., Szentágothai, J.: Golgi type II interneurons in the neuronal circuit of the monkey lateral geniculate nucleus. Exp. Brain Res. 17, 18–34 (1973)

    Google Scholar 

  • Peters, A., Palay, S.L.: The morphology of laminae A and A 1 of the dorsal nucleus of the lateral geniculate body of the cat. J. Anat. (Lond.) 100, 451–466 (1966)

    Google Scholar 

  • Rakic, P.: Local circuit neurons. NRP Bulletin 13, 299–313 (1975)

    Google Scholar 

  • Rall, W., Shepherd, G.M., Reese, T.S., Brightman, M.W.: Dendro-dendritic synaptic pathway for inhibition in the olfactory bulb. J. Neurophysiol. 14, 44–56 (1966)

    Google Scholar 

  • Ralston, H.J. III.: The fine structure of neurons in the dorsal horn of the cat spinal cord. J. comp. Neurol. 132, 275–302 (1968)

    Google Scholar 

  • Ralston, H.J. III.: Evidence for presynaptic dendrites and a proposal for their mechanism of action. Nature (Lond.) 230, 585–587 (1971)

    Google Scholar 

  • Ralston, H.J. III., Herman, M.M.: The fine structure of neurons and synapses in the ventrobasal thalamus of the cat. Brain Res. 14, 77–97 (1969)

    Google Scholar 

  • Reese, T.S., Brightman, U.V.: Electron microscopic studies on the rat olfactory bulb. Anat. Rec. 151, 492 (1965)

    Google Scholar 

  • Rinvik, E., Grofová, I.: Light and electron microscopical studies of the normal nuclei ventralis lateralis and ventralis anterior thalami in the cat. Anat. Embryol. 146, 57–93 (1974)

    Google Scholar 

  • Scheibel, M.E., Scheibel, A.B.: The organization of the ventral anterior nucleus of the thalamus. A Golgi study. Brain Res. 1, 250–268 (1966)

    Google Scholar 

  • Scheibel, M.E., Davies, T.L., Scheibel, A.B.: An unusual axonless cell in the thalamus of adult cat. Exp. Neurol. 36, 512–518 (1972)

    Google Scholar 

  • Sétáló, G., Székely, G.: The presence of membrane specializations indicative of somatodendritic synaptic junctions in the optic tectum of the frog. Exp. Brain Res. 4, 237–242 (1967)

    Google Scholar 

  • Shepherd, G.M.: The neuron doctrine: A revision of functional concept. Yale J. Biol. Med. 45, 584–599 (1972)

    Google Scholar 

  • Symmes, D., Anderson, K.V.: Reticular modulation of higher auditory centers in monkey. Exp. Neurol. 18, 161–176 (1967)

    Google Scholar 

  • Szentágothai, J.: The structure of the synapse in the lateral geniculate body. Acta anat. (Basel) 55, 166–185 (1963)

    Google Scholar 

  • Szentágothai, J.: Models of specific neuron arrays in thalamic relay nuclei. Acta morph. Acad. Sci. hung. 15/2, 113–124 (1967)

    Google Scholar 

  • Szentágothai, J., Arbib, M.A.: Conceptual models of neuronal organization. NRP Bulletin 12, 307–510 (1974)

    Google Scholar 

  • Szentágothai, J., Hámori, J., Tömböl, T.: Degeneration and electron microscopic analysis of the synaptic glomeruli in the lateral geniculate body. Exp. Brain Res. 2, 283–301 (1966)

    Google Scholar 

  • Tömböl, T.: Short neurons and their synaptic relations in the specific thalamic nuclei. Brain Res. 3, 307–326 (1966/1967)

    Google Scholar 

  • Tömböl, T.: Two types of short axoned (Golgi 2nd) interneurons in the specific thalamic nuclei. Acta morph. Acad. Sci. hung. 17, 285–297 (1969)

    Google Scholar 

  • Uchizono, K.: Characteristics of excitatory and inhibitory synapses in the central nervous system of the cat. Nature (Lond.) 207, 642–643 (1965)

    Google Scholar 

  • Uchizono, K.: Inhibitory and excitatory synapses in vertebrate and invertebrate animals. In: Structure and function of inhibitory neuronal mechanisms. pp. 33–59. (Eds. C. von Euler, S. Skoglund and U. Söderberg). Oxford-London-Edinburgh-New York: Pergamon Press 1968

    Google Scholar 

  • Valverde, F.: The neuropil in superficial layers of the superior colliculus of the mouse. A correlated Golgi and electron microscopic study. Z. Anat. Entwickl.-Gesch. 142, 117–147 (1973)

    Google Scholar 

  • Watanabe, T.I., Yanagisawa, K., Kanzaki, J., Katsuki, Y.: Cortical efferent flow influencing unit responses of medial geniculate body to sound stimulation. Exp. Brain Res. 2, 302–317 (1966)

    Google Scholar 

  • Wong, M.T.: Somato-dendritic and dendro-dendritic synapses in the squirrel monkey lateral geniculate nucleus. Brain Res. 20, 135–139 (1970)

    Google Scholar 

  • Wong-Riley, M.T.: Neuronal and synaptic organization of the normal dorsal lateral geniculate nucleus of the squirrel monkey, Simiri sauriens. J. comp. Neurol. 144, 25–60 (1972)

    Google Scholar 

Download references

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Majorossy, K., Kiss, A. Types of interneurons and their participation in the neuronal network of the medial geniculate body. Exp Brain Res 26, 19–37 (1976). https://doi.org/10.1007/BF00235247

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