Summary
Adaptability of the horizontal vestibulo-ocular reflex (HVOR) and the optokinetic response (OKR) was examined in alert albino rabbits during sustained runs lasting 5–12 h under four different stimulus conditions. (1) Sinusoidal rotation of the rabbit in darkness by 5 ° at 1/10 Hz, or (2) sinusoidal movement of a vertical slit light by 2.5 ° or 5 ° at 1/10 Hz around the optical axis of the stationary rabbit, affected the gain of neither the HVOR nor the OKR. (3) Combination of the stimulus as in (1) with the stationary slit light increased the gain of the HVOR gradually. A plateau at about 140% of the initial control was reached in 5 h. (4) Combination of the stimulus as in (1) with the slit light movement by 10 ° in phase with the turntable decreased the HVOR gain gradually, a plateau being obtained at about 70 % of the initial control in 5 h. Changes of the HVOR gain induced in conditions (3) and (4) were not frequency-specific and accompanied by no significant modification of either the gain or phase of the OKR or the linear property of HVOR-OKR interaction. A small but significant change of the HVOR phase was also detected under the condition (3) but not (4).
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Baarsma, E.A., Collewijn, H.: Vestibulo-ocular and optokinetic reactions to rotation and their interaction in the rabbit. J. Physiol. (Lond.)238, 603–625 (1974)
Batini, C., Ito, M., Kado, R.T., Miyashita, Y.: Interaction between the horizontal vestibulo-ocular reflex and optokinetic response in rabbits. Exp. Brain Res.37, 1–15 (1979)
Collewijn, H., Grootendorst, A.F.: Adaptation of the rabbit's vestibulo-ocular reflex to modified visual input: Importance of stimulus conditions. Arch. Ital. Biol.116, 273–280 (1978)
Collewijn, H., Kleinschmidt, H.J.: Vestibulo-ocular and optokinetic reactions in the rabbit: Changes during 24 h of normal and abnormal interaction. In: Basic mechanisms of ocular motility and their clinical implications (ed. G. Lennerstrand, and P. Bach-y-Rita), pp. 477–483. Oxford, New York: Pergamon 1975
Collewijn, H., Winterson, B.J., Dubois, M.F.W.: Albino rabbit's optokinetic eye movements: Inversion in anterior visual field. Science199, 1351–1353 (1978)
Conover, W.J.: Practical nonparametric statistics, pp. 121–126. New York: Wiley 1971
Gonshor, A., Melvill Jones, G.: Short-term adaptive changes in the human vestibulo-ocular reflex arc. J. Physiol. (Lond.)256, 361–379 (1976a)
Gonshor, A., Melvill Jones, G.: Extreme vestibulo-ocular adaptation induced by prolonged optical reversal of vision. J. Physiol. (Lond.)256, 381–414 (1976b)
Ito, M.: Neurophysiological aspects of the cerebellar motor control system. Int. J. Neurol.7, 162–176 (1970)
Ito, M.: Neural design of the cerebellar motor control system. Brain Res.40, 81–84 (1972)
Ito, M.: The control mechanisms of cerebellar motor systems. In: The neurosciences, third study program (ed. F.O. Schmitt and F.G. Worden), pp. 293–303. Boston: MIT Press 1974
Ito, M., Shiida, T., Yagi, N., Yamamoto, M.: The cerebellar modification of rabbit's horizontal vestibulo-ocular reflex induced by sustained heard rotation combined with visual stimulation. Proc. Jpn. Acad.50, 85–89 (1974)
Kleinschmidt, H.J., Collewijn, H.: A search for habituation of vestibulo-ocular reactions to rotatory and linear sinusoidal accelerations in the rabbit. Exp. Neurol.47, 257–267 (1975)
Lindqvist, E.F.: Design and analysis of experiments in psychology and education, pp. 1–393. Boston, New York: Houghton Mifflin 1953
Magnus, R.: Körperstellung. Berlin: Springer 1924
Melvill Jones, G., Davies, P.: Adaptation of cat vestibulo-ocular reflex to 200 days of optically reversed vision. Brain Res.103, 551–554 (1976)
Miles, F.A., Fuller, J.H.: Adaptive plasticity in the vestibulo-ocular responses of the rhesus monkey. Brain Res.80, 512–516 (1974)
Robinson, D.A.: Adaptive gain control of the vestibulo-ocular reflex by the cerebellum. J. Neurophysiol.39, 954–969 (1976)
Schairer, J.O., Bennett, M.V.L.: Adaptive gain control in vestibulo-ocular reflex of goldfish. Abst. Soc. Neurosci.3, 157 (1977)
Shiraki, T.: Response increase in optokinetic nystagmus. (in Japanese) Practica Otologica60, 970–992 (1967)
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On leave from Nencki Institute of Experimental Biology, Warsaw (from Jan. 1977 to Jan. 1978) and supported by a Polish-Japanese Cultural Relations Program Fellowship
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Ito, M., Jastreboff, P.J. & Miyashita, Y. Adaptive modification of the rabbit's horizontal vestibulo-ocular reflex during sustained vestibular and optokinetic stimulation. Exp Brain Res 37, 17–30 (1979). https://doi.org/10.1007/BF01474250
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DOI: https://doi.org/10.1007/BF01474250