Summary
The ascending and descending components of the medial forebrain bundle (MFB) were investigated by means of horseradish peroxidase (HRP) with a sensitive substrate. The HRP was injected iontophoretically into the MFB at various levels from the anterior commissure to the posterior hypothalamus. In order to prevent the diffusion of HRP to other brain areas, a double micropipette system was used. The descending components of the MFB are derived from (1) the anterior cingulate area, infra- or prelimbic area, and sulcal cortex, (2) the lateral septal nucleus and diagonal band, (3) the bed nucleus of the stria terminalis, (4) the paraventricular nucleus (5) the substantia innominata, (6) the amygdaloid complex (AM), (7) the ventromedial (VM) and dorsomedial (DM) hypothalamic nuclei, (8) the entopeduncular nucleus and (9) nucleus periventricularis stellatocellularis. The ascending components of the MFB originate in: (1) the medial preoptic nucleus, (2) the nucleus periventricularis stellatocellularis and rotundocellularis, (3) the posterior hypothalamic nucleus, (4) the parafascicular nucleus, (5) the ventral premammillary nucleus, (6) the substantia grisea periventricularis, (7) the lateral habenular nucleus, (8) the VM and DM, (9) the paratenial nucleus, (10) the AM and (11) the arcuate nucleus.
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Abbreviations
- a:
-
nucleus accumbens
- abl:
-
nucleus amygdaloideus basalis, pars lateralis
- abm:
-
nucleus amygdaloideus basalis, pars medialis
- ac:
-
nucleus amygdaloideus centralis
- AC:
-
anterior cingulate area
- al:
-
nucleus amygdaloideus lateralis
- am:
-
nucleus amygdaloideus medialis
- ar:
-
nucleus arcuatus
- CC:
-
tractus corporis callosi
- CSDV:
-
commissura supraoptica dorsalis, pars ventralis
- DB:
-
diagonal band
- DM:
-
nucleus dorsomedialis hypothalami
- EP:
-
nucleus entopeduncularis
- ha:
-
nucleus anterior hypothalami
- hl:
-
nucleus lateralis hypothalami
- hp:
-
nucleus posterior hypothalami
- IL:
-
infralimbic area of frontal cortex
- lh:
-
nucleus habenulae lateralis
- LH1 :
-
medial forebrain bundle (MFB) at the level of commissura anterior
- LH2 :
-
lateral preoptic area
- LH3 :
-
MFB at the level of the nucleus anterior hypothalami
- LH4 :
-
MFB at the level of the nucleus ventromedialis hypothalami
- LH5 :
-
MFB at the level of the nucleus posterior hypothalami
- MFB:
-
medial forebrain bundle
- pf:
-
nucleus parafascicularis
- PL:
-
prelimbic area of frontal cortex
- pol:
-
nucleus preopticus lateralis
- pom:
-
nucleus preopticus medialis
- posc:
-
nucleus preopticus, pars suprachiasmatica
- pt:
-
nucleus parataenialis
- pv:
-
nucleus premamillaris ventralis
- PV:
-
nucleus paraventricularis
- pvs:
-
nucleus periventricularis stellatocellularis
- pvr:
-
nucleus periventricularis rotundocellularis
- SC:
-
sulcal cortex
- SGPV:
-
substantia grisea periventricularis
- SI:
-
substantia innominata
- SL:
-
lateral septal nucleus
- ST:
-
bed nucleus of stria terminalis
- sum:
-
nucleus supramamillaris
- TO:
-
tractus opticus
- tmm:
-
nucleus medialis thalami, pars medialis
- VM:
-
nucleus ventromedialis hypothalami
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The nomenclature used in this paper is according to König and Klippel's Stereotaxic Atlas (1967).
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Shiosaka, S., Tohyama, M., Takagi, H. et al. Ascending and descending components of the medial forebrain bundle in the rat as demonstrated by the horseradish peroxidase-blue reaction. Exp Brain Res 39, 377–388 (1980). https://doi.org/10.1007/BF00239302
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DOI: https://doi.org/10.1007/BF00239302