Summary
Optic axons were cut in the goldfish optic nerve or tectum, filled with horseradish peroxidase and traced in tectal wholemounts. Many of them ran in conspicuous fascicles which curved across the tectum. Axons from central nasal retina, which ran in the most rostral fascicles, turned abruptly as they left these fascicles; ran caudally in a diffuse, parallel array for up to half the tectal length; and passed beneath more caudal fascicles to innervate the caudal half-tectum. Axons from peripheral nasal retina ran in the most caudal fascicles and terminated near their turning-points. Axons from temporal retina entered the tectum at its rostral margin and ran caudally from their points of entry to innervate the rostral halftectum. The resultant pattern was entirely consistent with the proposal that a slow caudal migration of optic terminals compensates during normal development for disparate modes of retinal and tectal growth.
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References
Attardi DG, Sperry RW (1963) Preferential selection of central pathways by regenerating optic fibers. Exp Neurol 7: 46–64
Cook JE (1982a) Most optic axons regenerating after nerve transection in goldfish take abnormal routes through the tectum. J Physiol (Lond) 330: 48–49P
Cook JE (1982b) Errant optic axons in the normal goldfish retina reach retinotopic tectal sites. Brain Res 250: 154–158
Cook JE (1983) Growth patterns of goldfish optic axons reveal boundaries between retinal quadrants. J Physiol (Lond) 334: 69–70P
Cook JE, Horder TJ (1977) The multiple factors determining retinotopic order in the growth of optic fibres into the optic tectum. Phil Trans R Soc (Lond) B 278: 261–276
Easter SS Jr, Stuermer CAO (1982) Evidence for naturally occurring movements of retinotectal terminals in goldfish. Soc Neurosci Abstr 8: 745
Gaze RM (1958) The representation of the retina on the optic lobe of the frog. Q J Exp Physiol 43: 209–214
Gaze RM, Chung SH, Keating MJ (1972) Development of the retinotectal projection in Xenopus. Nature New Biol 236: 133–135
Gaze RM, Keating MJ, Chung SH (1974) The evolution of the retinotectal map during development in Xenopus. Proc R Soc (Lond) B 185: 301–330
Gaze RM, Keating MJ, Ostberg A, Chung SH (1979) The relationship between retinal and tectal growth in larval Xenopus: Implications for the development of the retinotectal projection. J Embryol Exp Morphol 53: 103–143
Horder TJ (1974) Changes of fibre pathways in the goldfish optic tract following regeneration. Brain Res 72: 41–52
Jacobson M (1977) Mapping the developing retinotectal projection in frog tadpoles by a double label autoradiographic technique. Brain Res 127: 55–67
Jacobson M, Gaze RM (1964) Types of visual response from single units in the optic tectum and optic nerve of the goldfish. Q J Exp Physiol 49: 199–209
Johns PR (1977) Growth of the adult goldfish eye. III. Source of the new retinal cells. J Comp Neurol 176: 343–358
Meek J, Schellart NAM (1978) A Golgi study of goldfish optic tectum. J Comp Neurol 182: 89–122
Meyer RL (1977) Eye-in-water electrophysiological mapping of goldfish with and without tectal lesions. Exp Neurol 56: 23–41
Meyer RL (1978) Evidence from thymidine labeling for continuing growth of retina and tectum in juvenile goldfish. Exp Neurol 59: 99–111
Meyer RL (1980) Mapping the normal and regenerating retinotectal projection of goldfish with autoradiographic methods. J Comp Neurol 189: 273–289
Pilgrim AJ (1981) A method for the demonstration of nerve fibres and terminals in goldfish tectal wholemounts. J Physiol (Lond) 317: 14P
Romeskie M, Sharma SC (1979) The goldfish optic tectum: A Golgi study. Neuroscience 4: 625–642
Straznicky K, Gaze RM (1971) The growth of the retina in Xenopus laevis: An autoradiographic study. J Embryol Exp Morphol 26: 67–79
Straznicky K, Gaze RM (1972) The development of the tectum in Xenopus laevis: An autoradiographic study. J Embryol Exp Morphol 28: 87–115
Stuermer CAO, Easter SS Jr (1982) Growth-related order of optic axons in goldfish tectum. Soc Neurosci Abstr 8: 451
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Cook, J.E., Rankin, E.C.C. & Stevens, H.P. A pattern of optic axons in the normal goldfish tectum consistent with the caudal migration of optic terminals during development. Exp Brain Res 52, 147–151 (1983). https://doi.org/10.1007/BF00237159
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DOI: https://doi.org/10.1007/BF00237159