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GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus of the rat: characterisation by combined Golgi-impregnation and immunocytochemistry

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Summary

Identified neurons in the dorsal lateral geniculate nucleus (dLGN) of the rat were studied using a Golgi/EM procedure in combination with post-embedding GABA immunocytochemistry. The results of this investigation identify clearly the GABA-immunoreactive nature of the two morphologically] distinct neuronal populations found within the rat dLGN — thalamocortical relay cells are GABA-immunonegative whilst the putative ‘interneurons’ are GABA-immunopositive. This immunocytochemical evidence strongly suggests that ‘interneurons’ synthesize and use GABA to mediate their local inhibitory synaptic mechanisms within the dLGN of the rat.

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Authors and Affiliations

  1. 1st Department of Anatomy, Semmelweis University Medical School, Tüzolto u. 58, H-1450, Budapest, Hungary

    P. L. A. Gabbott, J. Somogyi & J. Hámori

  2. Brain Research Group, Department of Biology, The Open University, Walton Hall, MK7 6AA, Milton Keynes, UK

    P. L. A. Gabbott & M. G. Stewart

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  1. P. L. A. Gabbott
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  2. J. Somogyi
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  3. M. G. Stewart
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  4. J. Hámori
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Gabbott, P.L.A., Somogyi, J., Stewart, M.G. et al. GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus of the rat: characterisation by combined Golgi-impregnation and immunocytochemistry. Exp Brain Res 61, 311–322 (1986). https://doi.org/10.1007/BF00239521

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  • DOI: https://doi.org/10.1007/BF00239521

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