Summary
Single unit spike activities of Purkinje cells in the cerebellar flocculus were examined during sustained horizontal sinusoidal oscillation (0.33 Hz, 2.5° peak-to-peak) of a striped screen around an alert pigmented rabbit. The floccular area specifically related to horizontal reflex eye movement (H-zone) was identified by means of local stimulation that induced abduction of the ipsilateral eye. In control states, simple spike discharge of most of the H-zone Purkinje cells was enhanced by backward screen movement and depressed by forward screen movement, while complex spike discharge was modulated reciprocally. After one-hour sustained oscillation of the screen, the gain of horizontal optokinetic eye movement response (HOKR) increased by 0.16 on average. Correspondingly, simple spike modulation in most of H-zone Purkinje cells tested significantly increased in amplitude, while complex spike modulation tended to decrease. No such systematic changes were observed in other Purkinje cells. These results are consistent with the hypothesis that the floccular H-zone Purkinje cells adaptively control the optokinetic eye movement through modification of the visual mossy fiber responsiveness under the influence of the retinal error signals conveyed by the visual climbing pathway.
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References
Balaban CD, Watanabe E (1984) Functional representation of eye movements in the flocculus of monkeys (Macaca fuscata). Neurosci Lett 49: 199–205
Batini C, Ito M, Kado RT, Jastreboff PJ, Miyashita Y (1979) Interaction between the horizontal vestibulo-ocular reflex and optokinetic response in the rabbits. Exp Brain Res 37: 1–15
Buettner UW, Büttner U (1979) Vestibular nuclei activity in the alert monkey during suppression of vestibular and optokinetic nystagmus. Exp Brain Res 37: 581–593
Cazin L, Precht W, Lannou J (1980) Firing characteristics of neurons mediating optokinetic responses to rat's vestibular neurons. Pflügers Arch 386: 221–230
Cohen B, Matsuo V, Raphen T (1977) Quantitative analysis of the velocity characteristics of optokinetic nystagmus and optokinetic after-nystagmus. J Physiol (Lond) 270: 321–344
Collewijn H (1981) The oculomotor system of the rabbit and its plasticity. Studies of brain function, Vol 5. Springer, Berlin Heidelberg New York
Collewijn H, Grootendorst AF (1979) Adaptation of optokinetic and vestibulo-ocular reflexes to modified visual input in the rabbit. In: Granit R, Pompeiano O (eds) Reflex control of posture and movement. Progress in Brain Research, Vol 50. Elsevier, Amsterdam, pp 771–781
Dufossé M, Ito M, Miyashita Y (1977) Functional localization in the rabbit's cerebellar flocculus determined in relationship with eye movements. Neurosci Lett 5: 273–277
Henn V, Young LR, Finley C (1974) Vestibular nucleus units in alert monkeys are also influenced by moving visual fields. Brain Res 71: 144–149
Hoddevik GH (1978) The projection from the nucleus reticularis tegmenti pontis onto the cerebellum in the cat. Anat Embryol 153: 227–242
Ito M (1970) Neurophysiological aspects of the cerebellar motor control system. Int J Neurol 7: 162–176
Ito M (1972) Neural design of the cerebellar motor control system. Brain Res 40: 81–84
Ito M (1974) Control mechanisms of cerebellar motor systems. In: Schmidt FO, Worden FG (eds) The neurosciences, third study program. MIT Press, Massachusetts, pp 293–303
Ito M (1982) Cerebellar control of the vestibulo-ocular reflexaround the flocculus hypothesis. Ann Rev Neurosci 5: 275–296
Ito M (1984) The cerebellum and neuronal control. Raven Press, New York
Ito M, Orlov I, Yamamoto M (1982) Topographical representation of vestibulo-ocular reflexes in rabbit cerebellar flocculus. Neuroscience 7: 1657–1664
Jastreboff PJ (1979) Evaluation and statistical judgment of neural responses to sinusoidal stimulation in cases with superimposed drift and noise. Biol Cybern 33: 113–120
Kawaguchi Y (1985) Two groups of secondary vestibular neurons mediating horizontal canal signals, probably to the ipsilateral medial rectus muscle, under inhibitory influences from the cerebellar flocculus in rabbits. Neurosci Res 2: 434–446
Leonard CS, Simpson JI (1986) Eye velocity related simple spike modulation of rabbit flocculus Purkinje cells during horizontal compensatory eye movements. In: Developments in Oculomotor Research Program (Abstract for the Satellite Symposium of XXX International Congress of IPUS at Gleneden Beach), pp 45
Maekawa K, Takeda T (1979) Origin of the mossy fiber projection to the cerebellar flocculus from the optic nerve in rabbits. In: Ito M, Tsukahara N, Kubota K, Yagi K (eds) Integrative control functions of the brain, Vol 1. Kohdansha, Tokyo, Elsevier Amsterdam, pp 110–112
Maekawa K, Takeda T, Kano M, Kusunoki M (1988) Collateralized climbing fiber projection to the flocculus and the nodulus of the rabbit. In: Strata P (ed) Olivo-cerebellar system in motor control. Springer, Berlin Heidelberg New York
Markert G, Büttner U (1985) Purkinje cell activity in the flocculus of alert monkey during optokinetic stimulation. Neurosci Lett Suppl 22: 40
Miles FA, Lisberger SG (1981) Plasticity in the vestibulo-ocular reflex: a new hypothesis. Ann Rev Neurosci 4: 273–299
Miyashita Y (1984) Eye velocity responsiveness and its proprioceptive component in the floccular Purkinje cells of the alert pigmented rabbit. Exp Brain Res 55: 81–90
Miyashita Y, Ito M, Jastreboff PJ, Maekawa K, Nagao S (1980) Effects upon eye movements of rabbits induced by severance of mossy fiber visual pathway to the cerebellar flocculus. Brain Res 198: 210–215
Miyashita Y, Nagao S (1984) Analysis of signal content of Purkinje cell responses to optokinetic stimuli in the rabbit cerebellar flocculus by selective lesions of brainstem pathway. Neurosci Res 1: 223–241
Nagao S (1983) Effects of vestibulocerebellar lesions upon dynamic characteristics and adaptation of vestibulo-ocular and optokinetic responses in pigmented rabbits. Exp Brain Res 53: 36–46
Nagao S (1984) Adaptive changes of floccular Purkinje cell responsiveness induced by sustained optokinetic and vestibular stimulation in pigmented rabbits. J Physiol Soc Jpn 46: 182
Nagao S, Ito M, Karachot L (1985) Eye fields in the cerebellar flocculus of pigmented rabbits determined with local electrical stimulation. Neurosci Res 3: 39–51
Simpson JI, Alley KE (1974) Visual climbing fiber input to rabbit vestibule-cerebellum: a source of direction-specific information. Brain Res 82: 302–308
Thach WT (1968) Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. J Neurophysiol 31: 785–797
Waespe W, Kenn V (1977) Neuronal activity in the vestibular nuclei of the alert monkey during vestibular and optokinetic stimulation. Exp Brain Res 27: 523–538
Waespe W, Henn V (1978) Conflicting visual-vestibular stimulation and vestibular nucleus activity in alert monkey. Exp Brain Res 33: 203–211
Waespe W, Henn V (1979) The velocity response of vestibular nucleus neurons during vestibular, visual, and combined angular accelerations. Exp Brain Res 37: 337–347
Watanabe E (1985) Role of the primate flocculus in adaptation of the vestibulo-ocular reflex. Neurosci Res 3: 20–38
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Nagao, S. Behavior of floccular Purkinje cells correlated with adaptation of horizontal optokinetic eye movement response in pigmented rabbits. Exp Brain Res 73, 489–497 (1988). https://doi.org/10.1007/BF00406606
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DOI: https://doi.org/10.1007/BF00406606