Summary
Five healthy volunteers were treated orally with lithium carbonate, sulphate, or chloride. There were no significant differences in area under time-concentration curves, half-lives, total body clearance or apparent distribution volumes between the various salts, either in plasma or in the RBC compartment. The carbonate salt did show a higher RBC/plasma distribution ratio than the other salts, which might possibly imply greater therapeutic effectiveness of this salt. Some considerations on the tolerability of various lithium salts are discussed.
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Altamura, A.C., Gomeni, R., Sacchetti, E. et al. Plasma and intracellular kinetics of lithium after oral administration of various lithium salts. Eur J Clin Pharmacol 12, 59–63 (1977). https://doi.org/10.1007/BF00561406
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DOI: https://doi.org/10.1007/BF00561406