Summary
Fourteen patients undergoing elective surgery were studied at two levels of gallamine dosage. Seven patients received a single bolus dose of 4 mg/kg, and the remainder received 6 mg/kg. The venous plasma concentration-time data from both groups were characterized in terms of a two-compartment open model. No significant differences in the various pharmacokinetic parameters were noted. However the distribution and clearance terms from these two patient groups were significantly higher than those obtained with a previous group of patients receiving lower (2 mg/kg) single and multiple doses. Assessment of neuromuscular twitch response showed that maximum blockade was attained in all patients within 5 min with the time to peak effect being dose dependent. Recovery from paralysis as assessed at 99, 95 and 90% paralysis indicated that the duration of action was similarly dose dependent. The concurrently measured plasma concentrations showed wide variation but were higher at more profound levels of paralysis. Arterial blood samples for 5 patients receiving the 4 mg/kg gallamine dose were taken simultaneously with the venous samples over the first sixty minutes. No significant arterio-venous differences in gallamine plasma concentration were noted at any time interval in all subjects.
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References
Agoston, S., Vermeer, G. A., Kersten, V. W., Scaf, A. H.: A preliminary investigation of the renal and hepatic excretion of gallamine triethiodide in man. Br. J. Anaesth.50, 345–351 (1978)
Cohen, E. N., Paulson, W. J., Elert, B.: Studies of d-tubocurarine with measurement of concentration in human blood. Anesthesiology18, 300–309 (1957)
Dal Santo, G.: Kinetics of distribution of radioactive labelled muscle relaxants. Investigations with14C-dimethyl-d-tubocurarine. Anesthesiology,25, 788–800 (1974)
Duvaldestin, P., Henzel, D., Gilles, M. R., Roze, C., Desmonts, J. M.: Etude de la pharmacocinetique de la gallamine chez l'homme. Anesth. Anal. Reanim34, 235–239 (1977)
Goldstein, A.: Biostatistics: an introductory text, p. 51. New York: Macmillan 1964
Moore, D. C., Mather, L. E., Bridenbraugh, P. O., Bridenbraugh, L. D., Balfour, R. I., Lysons, D. F., Horton, W. G.: Arterial and venous plasma levels of bupivacaine following epidural and intercostal nerve block. Anesthesiology45, 39–45 (1976)
Pedersen, P. V.: Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN — and a new program FUNFIT. J. Pharmacokinet. Biopharm.5, 513–531 (1977)
Ramzan, M. I., Triggs, E. J., Shanks, C. A.: Pharmacokinetic studies in man with gallamine tiethiodide I. Single and multiple clinical doses. Eur. J. Clin. Pharmacol.17, 135–143 (1980)
Sheiner, L. B., Stanski, D. R., Vozeh, S., Miller, R. D., Ham, J.: Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin. Pharmacol. Ther.25, 358–371 (1979)
Somogyi, A. A.: The clinical pharmacology of pancuronium bromide. Ph. D. Thesis, University of Sydney (1978)
Wagner, J. G.: Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data. J. Pharmacokinet. Biopharm.4, 443–467 (1976)
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Ramzan, M.I., Triggs, E.J. & Shanks, C.A. Pharmacokinetic studies in man with gallamine triethiodide. Eur J Clin Pharmacol 17, 145–152 (1980). https://doi.org/10.1007/BF00562623
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DOI: https://doi.org/10.1007/BF00562623