Summary
Prednisolone was measured in plasma, saliva and urine at various times after a single dose. Peak plasma prednisolone levels were observed about 1 h after the dose. Saliva prednisolone levels were measurable for at least 3 h after dosing but showed no consistent relationship to either total or free plasma prednisolone concentrations. Unchanged prednisolone in amounts up to 14% of the dose administered was found in the 24 h urine and most of it was excreted in the first 5 h.
Similar content being viewed by others
References
Colburn WA, Buller RH (1973) Radioimmunoassay for prednisolone. Steroids 21: 833–846
Chakraborty J, English J, Marks V, Dumasia MC, Chapman DJ (1970) A radioimmunoassay method for prednisolone: comparison with the competitive protein-binding method. Br J Clin Pharmacol 3: 903–906
Morrison PJ, Bradbrook ID, Rogers HJ (1977) Plasma prednisolone levels from enteric and non-enteric-coated tablets estimated by an original technique. Br J Clin Pharmacol 4: 597–603
Powell LW, Axelson E (1972) Corticosteroids in liver disease: Studies on the biological conversion of prednisone and plasma protein binding. Gut 13: 690–696
Kozower M, Veatch L, Kaplan MM (1974) Decreased clearance of prednisolone, a factor in the development of corticosteroid side effects. J Clin Endocrinol Met 38: 407–412
Petereit LB, Meikle AW (1977) Effectiveness of prednisolone during phenytoin therapy. Clin Pharmacol Ther 22: 912–916
Tembo AV, Hallmark MR, Sakmar E, Bachman HG, Weidler DJ, Wagner JG (1977) Bioavailability of prednisolone tablets. J Pharmacokinet Biopharm 5: 257–270
Elliot PR, Powell-Tuck J, Gillespie PE, Laidlow JH, Lennard-Jones JE, English J, Chakraborty J, Marks V (1979) Prednisolone absorption in acute colitis. Gut 21: 49–51
Henderson RG, Wheatley T, English J, Chakraborty J, Marks V (1979) Variation in plasma prednisolone concentrations in renal transplant patients given enteric-coated prednisolone. Br Med J 1: 1534–1536
Graham G, Rowland M (1972) Application of salivary salicylate data to biopharmaceutical studies of salicylates. J Pharm Sci 8: 1219–1222
Koysoko R, Ellis EF, Levy G (1974) Relationship between theophylline concentration in plasma and saliva in man. Clin Pharmacol Ther 15: 454–460
Matin SB, Wan S Han, Karam JH (1974) Pharmacokinetics of tolbutamide: prediction by concentration in saliva. Clin Pharmacol Ther 16: 1052–1058
Huffman DH (1975) Relationship between digoxin concentrations in serum and saliva. Clin Pharmacol Ther 17: 310–312
Vessel ES, Passananti GT, Glenwright PA, Dvorchik BH (1975) Studies on the disposition of antipyrine, aminopyrine and phenacetin using plasma, saliva and urine. Clin Pharmacol Ther 18: 259–272
Reynolds F, Ziroyanis PN, Jones NF, Smith SE (1976) Salivary phenytoin concentrations in epilepsy and chronic renal failure. Lancet 2: 384–389
Walker RF, Fahmy DR, Read GF (1978) Adrenal status assessed by direct radioimmunoassay of cortisol in whole saliva or parotid fluid. Clin Chem 24: 1460–1463
Walker RF, Read GF, Hughes IA, Fahmy DR (1979) Radioimmunoassay of 17 α-hydroxyprogesterone in saliva, parotid fluid and plasma of congenital adrenal hyperplasia patients. Clin Chem 25: 542–545
Mattingley D (1962) A simple fluorimetric method for the estimation of free 11-hydroxycorticosteroids in human plasma. J Clin Pathol 15: 374–379
Weder HG, Schildknecht J, Kesselring P (1971) A new equilibrium dialyzing system. Am Lab Oct: 15–21
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chakraborty, J., Hayes, M., English, J. et al. Prednisolone concentrations in plasma, saliva and urine. Eur J Clin Pharmacol 19, 79–81 (1981). https://doi.org/10.1007/BF00558389
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00558389