Summary
Cadralazine (ISF 2469) was administered to 24 hypertensive patients in single oral doses of 7.5, 10, 15, 20 and 30 mg, according to a single-blind, placebo-controlled, within-patient change-over design. The study was done in 2 stages: in the first a range including the upper and lower doses was studied (7.5, 15, 30 mg and placebo), and in the second the range of doses was restricted (10, 15, 20 mg and placebo). The drug produced a significant decrease in blood pressure in the supine and standing positions. The decrease became clinically important starting from the 15 mg dose. Its action was still significant 12 h after administration. A significant increase in heart rate was also observed. All the effects were correlated with the dose. Side effects occurred mainly after the 30 mg dose. Thus, cadralazine, in a single oral dose in man, showed good antihypertensive activity starting from the 15 mg dose, and its effect was dose-related, slow in onset and long-lasting.
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References
Pifferi G, Parravicini F, Scarpitta G, Semeraro C (1978) Synthesis and anti-hypertensive activity of new 6-substituted 3-alkyl and 3-acyl-hydrazinopyridazines. 6th Int Symp Med Chemistry, Brighton, September 4–7, p 17
Carpi C, Dorigotti L, Semeraro C (1978) Pharmacological profile of a new antihypertensive drug: Ethyl 2-[6-[(2-hydroxipropyl) ethylamino]-3-pyridazinyl] hydrazinecarboxylate (ISF 2469). Abstract: 7th Int Congress of Pharmacology, Paris — July 16–21, 2700
Semeraro C, Dorigotti L, Banfi S, Carpi C (1981) Pharmacological studies on cadralazine: a new antihypertensive vasodilator drug. J Cardiovasc Pharmacol 3: 455–467
Van Brummelen P, Bühler FR, Kiowski W, Bolli P, Bertel O (1979) Antihypertensive efficacy of a new long acting vasodilator, ISF 2469, in combination with a betablocker and a diuretic. Int J Clin Pharmacol 17: 380–385
Amann FW, Bühler FR (1979) Long-term antihypertensive therapy with a new vasodilator, ISF 2469, in combination with a betablocker and a diuretic. Clin Eur 6: 1028–1034
Patterson HD, Lucas HL (1962) Change-over designs. Tech Bull 147, — North Carolina Agricultural Experiment Station and United States Department of Agriculture
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Catalano, M., Parini, J. & Libretti, A. Cadralazine (ISF 2469): Dose-related antihypertensive activity after single oral administration to patients. Eur J Clin Pharmacol 24, 157–161 (1983). https://doi.org/10.1007/BF00613810
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DOI: https://doi.org/10.1007/BF00613810