Summary
The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pleural fluid in all cases was 2–3fold longer than from serum, which shows a difference between the kinetic elimination processes of the antibiotic from the two fluids. The slow elimination of cefoxitin from pleural fluid facilitates its accumulation in this compartment during a multiple dosage regimen.
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Otero, M.J., Garcia, M.J., Barrueco, M. et al. Pharmacokinetics of cefoxitin administered by i.v. infusion to patients with a pleural effusion. Eur J Clin Pharmacol 26, 389–392 (1984). https://doi.org/10.1007/BF00548772
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DOI: https://doi.org/10.1007/BF00548772