Summary
Eleven patients on long-term prednisone treatment were studied on two occasions separated by 45 to 325 days. In 10 patients the total body clearance of prednisolone only changed about 10%. In one case a 78.5% decrease was observed after stopping treatment with rifampicin and isoniazide. No association was found between the prednisone dose rate (mg/kg per month), patient age or mean endogenous plasma hydrocortisone level and prednisolone clearance/kg. The results indicate considerable intra-individual consistency of prednisolone kinetics if other conditions are not changed.
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Langhoff, E., Flachs, H., Ladefoged, J. et al. Intra-individual consistency of prednisolone kinetics during long-term prednisone treatment. Eur J Clin Pharmacol 26, 651–653 (1984). https://doi.org/10.1007/BF00543505
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DOI: https://doi.org/10.1007/BF00543505