Skip to main content
Log in

Amphetamine secretion in breast milk

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

The excretion of amphetamine in human breast milk was studied in a nursing mother with narcolepsy, who was treated with 20 mg daily of a racemic preparation of amphetamine. The concentration of amphetamine was 3 and 7 times higher in breast milk than in maternal plasma on the 10th and 42nd days after delivery. Small amounts of amphetamine were found in urine samples from the infant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Findlay JWA (1983) The distribution of some commonly used drugs in human breast milk. Drug Metab Rev 14:653–684

    CAS  PubMed  Google Scholar 

  2. Kaneko S, Sato T, Suzuki K (1979) The levels of anticonvulsants in breast milk. Br J Clin Pharmacol 7:624–626

    CAS  PubMed  Google Scholar 

  3. Rasmussen F (1983) Excretion of drugs by milk. In: Brodie BB, Gilette JR (eds) Concepts in biochemical pharmacology. Springer, Berlin Heidelberg New York (Handbook of experimental pharmacology, vol 28/1, pp 390–402

    Google Scholar 

  4. Wilson JT, Brown RD, Cherek DR, Daily JW, Hilman B, Jobe PC, Manno BR, Manno JE, Redetzki HM, Stewart JJ (1980) Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet 5:1–66

    CAS  PubMed  Google Scholar 

  5. Steen B, Rane A, Lönnerholm G, Falk O, Elwin C-E, Sjöqvist F (1982) Phenytoin excretion in human breast milk and plasma levels in nursed infants. Ther Drug Monit 4:331–334

    CAS  PubMed  Google Scholar 

  6. Milkovitch L, Berg BJ van den (1977) Effects of antenatal exposure to anoretic drugs. Am J Obstet Gynecol 129:637

    Google Scholar 

  7. Nora JJ (1971) Ethiological factors in congenital heart diseases. Pediatr Clin North Am 18:4

    Google Scholar 

  8. Sussman S (1983) Narcotic and amphetamine use during pregnancy. Am J Dis Child 106:125–130

    Google Scholar 

  9. Billing L, Eriksson M, Larsson G, Zetterström R (1980) Amphetamine addiction and pregnancy. Acta Paediat Scand 69:675–680

    CAS  PubMed  Google Scholar 

  10. Liedholm H, Melander A, Bitzen P-O, Helm G, Lönnerholm G, Mattiasson I, Nilsson B, Wåhlin-Boll E (1981) Accumulation of atenolol and metoprolol in human breast milk. Eur J Clin Pharmacol 20:229–231

    Article  CAS  PubMed  Google Scholar 

  11. Kulas J, Lunell N-O, Steen B, Rosing U, Rane A (in press) (1984) Acta Obstet Gynecol Scand

  12. Steen B, Rane A (1982) Clindamycin passage into human milk. Br J Clin Pharmacol 13:661–664

    CAS  PubMed  Google Scholar 

  13. Yurchah AM, Jusko WJ (1976) Theophylline secretion into breast milk. Pediatrics 57:518–520

    Google Scholar 

  14. Lundborg P, Engel J (1978) Development of monoamine neurons and effects of psychotropic drugs. In: Deniker P, Raduco-Thomas C, Villeneuve A (eds) Neuro-psychopharmacology, vol 2. Pergamon Press, Oxford

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Steiner, E., Villén, T., Hallberg, M. et al. Amphetamine secretion in breast milk. Eur J Clin Pharmacol 27, 123–124 (1984). https://doi.org/10.1007/BF02395219

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02395219

Key words

Navigation