Summary
The effect of haemodialysis on mebendazole kinetics has been studied in a patient receiving both mebendazole therapy and haemodialysis. The procedure of haemodialysis did not influence the plasma concentration — time profiles or the mean daily plasma levels. The arterio-venous difference in the dialyser was negligible and no mebendazole could be detected in the dialysate. Protein binding of mebendazole was 90% before dialysis and 88% during dialysis and not significantly different from the binding in patients without renal disease (91.4±1.9%, n=22).
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Allgayer, H., Zähringer, J., Bach, P. et al. Lack of effect of haemodialysis on mebendazole kinetics: Studies in a patient with echinococcosis and renal failure. Eur J Clin Pharmacol 27, 243–245 (1984). https://doi.org/10.1007/BF00544053
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DOI: https://doi.org/10.1007/BF00544053