Summary
Twenty volunteers aged between 20 and 57 years were given 197 mg of theophylline (as lysine theophylline) by iv infusion over 5 minutes to test the hypothesis that within the adult age range theophylline clearance declines with age. Samples were assayed for theophylline using the EMIT assay and clearance was determined by standard methods. Clearance values were 0.73 ml/min/kg below age 38 years and 0.75 ml/min/kg at and above age 38 years. Multiple regression analysis using age as a continuous variable showed no relationship between age and clearance.
Similar content being viewed by others
References
Antal EJ, Kramer PA, Mercik SA, Chapron DJ, Lawson IR (1981) Theophylline kinetics in advanced age. Br J Clin Pharmacol 12: 637–645
Chang J, Gotcher S, Gushaw JB (1982) Homogeneous enzyme immunoassay for theophylline in serum and plasma. Clin Chem 28: 361–367
Cusack B, Kelly JG, Lavan J, Noel J, O'Malley K (1980) Theophylline kinetics in relation to age: The importance of smoking. Br J Clin Pharmacol 10: 109–114
Fox RW, Samaan S, Bukantz SC, Lockey RF (1983) Theophylline kinetics in a geriatric group. Clin Pharmacol Ther 34: 60–67
Gal P, Jusko WJ, Yurchak AM, Franklin BA (1978) Theophylline disposition in obesity. Clin Pharmacol Ther 23: 438–444
Grygiel JJ, Birkett DJ (1980) Effect of age on patterns of theophylline metabolism. Clin Pharmacol Ther 28: 456–462
Jackson SHD, Wright JM (1983) Sustained serum theophylline concentrations during chronic twice daily administration of a slow release preparation. Eur J Clin Pharmacol 24: 205–208
Johnston A, Aldous M, Hedges A, Weerasuriya K, Freedman A, Turner P (1983) The pharmacokinetics of lysine theophylline, a new soluble theophylline, in human volunteers. Postgrad Med J 59: 86–87
Johnston A, Woollard RC (1983) STRIPE: An interactive computer program for the analysis of drug pharmacokinetics. J Pharmacol Methods 9: 193–200
Jusko WJ, Gardner MJ, Mangione A, Schentag JJ, Koup JR, Vance JW (1979) Factors affecting theophylline clearance: Age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates and ethanol. J Pharm Sci 68: 1358–1366
Jusko WJ, Koup JR, Vance JW, Schentag JJ, Kuritzky P (1977) Intravenous theophylline therapy — nomogram guidelines. Ann Intern Med 86: 400–404
Linday LA, Drayer DE, Khan MAA, Cicalese C, Reidenberg MM (1984) Pubertal changes in net renal tubular secretion of digoxin. Clin Pharmacol Ther 35: 438–446
Melethil S, Carlson JD, Haug MT (1982) Predictability of theophylline levels. Drug Intell Clin Pharm 16: 695–697
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jackson, S.H.D., Wiffen, J.K., Johnston, A. et al. The relationship between clearance of theophylline and age within the adult age range. Eur J Clin Pharmacol 29, 177–179 (1985). https://doi.org/10.1007/BF00547418
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00547418