Summary
Plasma concentrations of nitrendipine were measured, after single (20 mg) oral doses, in young healthy volunteers.
On three occasions the subjects ingested the dose having fasted overnight. Data from these three occasions were used to assess variability in nitrendipine pharmacokinetics and both inter- and intra-subject variability were high.
On a fourth occasion, the subjects took the tablet after a standard meal.
The effects of food on nitrendipine pharmacokinetics, based on the comparison of data from the first fasting visit and the food visit, were negligible.
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References
Arnoff GR, Sloan RS (1985) Nitrendipine kinetics in normal and impaired renal function. Clin Pharmacol Ther 38 [2]: 212–218
Edgar B, Collste P, Haglund K, Regardh C-G (1985) Pharmacokinetics of felodipine after an acute dose and after repeated administration. Br J Clin Pharmacol 20 [3]: 249P-250P
Frohlich ED (1985) Introduction: Calcium channel blocking drugs: A new and important class of antihypertensive agents. Am J Med 79: 1
Jack DB, Quarterman CP, Zaman R, Kendall MJ (1982) Variability of beta-blocker pharmacokinetics in young volunteers. Eur J Clin Pharmacol 23: 37–42
Kann J, Krol GJ, Raemsch KD, Burkholder DE, Levitt MJ (1984) Bioequivalance and metabolism of nitrendipine administered orally to healthy volunteers. J Cardiovasc Pharmacol 6, S968-S974
Lewis JG (1983) Adverse reactions to calcium antagonists. Drugs 25: 196–222
Melander A, McLean A (1983) Influence of food intake on presystemic clearance of drugs. Clin Pharmacokinet 8: 280–296
Raemsch K-D, Sommer J (1983) Pharmacokinetics and metabolism of nifedipine. Hypertension 5 [4]: 1118–1124
Rosseel MT, Bogaert MG (1983) Determination of nifedipine in human plasma by capillary gas chromatography with nitrogen detection. J Chromatogr 279: 675–680
Ruddel H, Schmieder R, Langewitz W, Neus J, Wagner O, von Eiff AW (1984) Efficacy of nitrendipine as baseline antihypertensive therapy. J Cardiovasc Pharmacol 6 [7]: S1049
Schamroth L (1980) The clinical use of intravenous verapamil. Am Heart J 100: 1070–1075
Welling PG, Tse FLS (1984) Factors contributing to variability in drug pharmacokinetics. I. Absorption. J Clin Hosp Pharm 9: 163–179
Wilkinson GR, Shand DG (1975) A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18 [4]: 377–390
Zelis R, Flaim SF (1982) Calcium blocking drugs for angina pectoris. Ann Rev Med 33: 465–478
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Lobo, J., Jack, D.B. & Kendall, M.J. Inter- and intra-subject variability of nitrendipine and the effects of food. Eur J Clin Pharmacol 32, 357–360 (1987). https://doi.org/10.1007/BF00543969
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DOI: https://doi.org/10.1007/BF00543969