Summary
The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days.
During prednisolone administration antipyrine clearance decreased from 54.9±14.8 to 51.7±14.6 ml/min (mean±SD; p<0.05).
The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.
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Loft, S., Simonsen, K., Evald, T. et al. Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease. Eur J Clin Pharmacol 33, 89–91 (1987). https://doi.org/10.1007/BF00610387
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DOI: https://doi.org/10.1007/BF00610387